Interactive Fly, Drosophila

Gaiano, N., Nye, J. S. and Fishell, G. (2000). Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron 26: 395-404.

Gallagher, C. M. and Knoblich. J. A. (2006). The conserved c2 domain protein Lethal (2) giant discs regulates protein trafficking in Drosophila. Dev. Cell. 11(5): 641-53. Medline abstract: 17084357

Ge, X., et al. (2004). Notch signaling in Drosophila long-term memory formation. Proc. Natl. Acad. Sci. 101: 10172-10176. 15220476

Ghabrial, A. S. and Krasnow, M. A. (2006). Social interactions among epithelial cells during tracheal branching morphogenesis. Nature 441(7094): 746-9. 16760977

Ghazi, A., Paul, L. and VijayRaghavan, K. (2003). Prepattern genes and signaling molecules regulate stripe expression to specify Drosophila flight muscle attachment sites. Mech. Dev. 120: 519-528. 12782269

Gho, M., et al. (1996). Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development 122: 1673-82

Gibson, M. C. and Schubiger, G. (2000). Peripodial cells regulate proliferation and patterning of Drosophila imaginal discs. Cell 103: 343-350.

Giebel, B., et al. (1999). The Notch signaling pathway is required to specify muscle progenitor cells in Drosophila. Mech. Dev. 86: 137-145.

Giniger, E., Jan, L.Y. and Jan, Y.N. (1993). Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch. Development 117 (2): 431-440.

Giniger, E. (1998). A role for Abl in Notch signaling. Neuron 20: 667-681.

Glise, B., Jones, D. L. and Ingham, P. W. (2002). Notch and Wingless modulate the response of cells to Hedgehog signaling in the Drosophila wing. Dev. Bio. 248: 93-106 . 12142023

Go, M. J., Eastman, D. S. and Artavanis-Tsakonas, S. (1998a). Cell proliferation control by Notch signaling in Drosophila development. Development 125: 2031-2040.

Go, M. J. and Artavanis-Tsakonas, S. (1998b). A genetic screen for novel components of the Notch signaling pathway during Drosophila bristle development. Genetics 150(1): 211-220

Goto, S., Taniguchi, M., Muraoka, M., Toyoda, H., Sado, Y., Kawakita, M. and Hayashi, S. (2001). UDP-sugar transporter implicated in glycosylation and processing of Notch. Nat. Cell Biol. 3: 816-822. 11533661

Gonsalves, F. C. and Weisblat. D. A. (2007). MAPK regulation of maternal and zygotic Notch transcript stability in early development. Proc. Natl. Acad. Sci. 104(2): 531-6. PubMed citation; Online text

González-Gáitan, M. and Jäckle, H. (1995). Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless. Development 121: 2313-2325

González-Gaitán, M. and Jäckle, H. (2000). Tip cell-derived RTK signaling initiates cell movements in the Drosophila stomatogastric nervous system anlage. EMBO Reports 1: 366-371. 11269504

Gonzalez-Reyes, A. and Johnston, D. S. (1998). Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis. Development 125(15): 2837-2846.

Good, K., et al. (2004). The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos. Development 131: 1967-1978. 15056620

Goode, S., et al. (1996). The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis. Development 122: 3863-3879

Goutte, C., et al. (2000). aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127(11): 2481-92. 10804188

Grammont, M., Dastugue, B. and Couderc, J. L. (1997). The Drosophila toucan (toc) gene is required in germline cells for the somatic cell patterning during oogenesis. Development 124(24): 4917-4926.

Grammont, M. and Irvine, K. D. (2001). fringe and Notch specify polar cell fate during Drosophila oogenesis. Development 128: 2243-2253

Grandbarbe, L., et al. (2003). Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process. Development 130: 1391-1402. 12588854

Grant, B. and Greenwald, I. (1997). Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans. Development 124, 637-644

Greenwood, A. L., Li, S., Jones, K. and Melton, D. A. (2007). Notch signaling reveals developmental plasticity of Pax4⁺ pancreatic endocrine progenitors and shunts them to a duct fate. Mech. Dev. 124(2): 97-107. Medline abstract: 17196797

Grego-Bessa, J., et al. (2007). Notch signaling is essential for ventricular chamber development. Dev. Cell 12(3): 415-29. Medline abstract: 17336907

Gu, Y., Hukriede, N. A. and Fleming, R. J. (1995). Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development 121: 855-865

Guo, M., Jan, L. Y. and Jan, Y. N. (1996). Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch. Neuron 17: 21-41

Guo, Y., et al. (1999). Drosophila presenilin is required for neuronal differentiation and affects Notch subcellular localization and signaling. J. Neurosci. 19(19): 8435-8442.

Gupta-Rossi, N., et al. (2004). Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. J. Cell Biol. 166(1): 73-83. 15240571

Gustafsson, M. V., et al. (2005). Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev. Cell 9(5): 617-28. 16256737

Haddon C., et al. (1998). Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant. Development 125(23): 4637-4644

Hald, J., et al. (2003). Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev. Biol. 260: 426-437. 12921743

Han, Z. and Bodmer, R. (2003). Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 130: 3039-3051. 12756185

Harris, J. G. and Filley, C. M. (2001). Cadasil: neuropsychological findings in three generations of an affected family. J. Int. Neuropsychol. Soc. 7: 768-774. 11575598

Hartenstein, A.Y., Rugendorff, A., Tepass, U. and Hartenstein, V. (1992). The function of the neurogenic genes during epithelial development in the Drosophila embryo. Development 116(4): 1203-1220

Hartenstein, V., Younossi-Hartenstein, A. and Lekven, A. (1994). Delamination and division in the Drosophila neuroectoderm: spatiotemporal pattern, cytoskeletal dynamics and common control by neurogenic and segment polarity genes. Dev. Biol. 165: 480-99

Hartenstein, V., Tepass, U. and Gruszynski-deFeo, E. (1996). Proneural and neurogenic genes control specification and morphogenesis of stomatogastric nerve cell precursors in Drosophila Dev. Biol. 173: 213-227

Hassan, B. A., et al. (2000). atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25: 549-561.

Hayward, P., Brennan, K., Sanders, P., Balayo, T., DasGupta, R., Perrimon, N. and Martinez Arias, A. (2005). Notch modulates Wnt signalling by associating with Armadillo/ß-catenin and regulating its transcriptional activity. Development 132: 1819-1830. 15772135

Hayward, P., Balayo, T. and Martinez Arias, A. (2006). Notch synergizes with axin to regulate the activity of armadillo in Drosophila. Dev. Dyn. 235(10): 2656-66. Medline abstract: 16881048

Henrique, D., et al. (1997). Maintenance of neuroepithelial progenitor cells by delta-notch signalling in the embryonic chick retina. Curr. Biol. 7(9): 661-670.

Hermann, G. J., Leung, B. and Priess, J. R. (2000). Left-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch signaling pathway. Development 127: 3429-3440

Higuchi, M., et al. (1995). Differential expression of Notch1 and Notch2 in developing and adult mouse brain. Brain Res. Mol. Brain Res. 29: 263-272

Hing, H. K., Sun, X. and Artavanis-Tsakonas, S. (1994). Modulation of wingless signaling by Notch in Drosophila. Mech Dev 47: 261-268

Hirsinger, E., et al. (2001). Notch signaling acts in postmitotic avian myogenic cells to control MyoD activation. Development 128: 107-116

Hitoshi, S., et al. (2002). Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev. 16: 846-858. 11937492

Hitoshi, S., et al. (2004). Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev. 18: 1806-1811. 15289455

Hoch, M. and Jackle, H. (1998). Kruppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila. EMBO J. 17(19): 5766-75.

Holland, L. Z., et al. (2001). Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates. Dev. Biol. 232: 493-507

Holley, S. A., et al. (2002). her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis. Development 129: 1175-1183. 11874913

Hori, K., et al. (2004). Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling. Development 131: 5527-5537. 15496440

Hori, S., et al. (1997). Notch homologue from Halocynthia roretzi is preferentially expressed in the central nervous system during ascidian embryogenesis. Dev. Genes Evol. 207: 371-380

Hsieh, J. J., et al. (1996). Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol. Cell. Biol. 16: 952-959

Hsieh, J. J., et al. (1997). Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J. Virol. 71(3): 1938-1945.

Hu, Q.D., et al. (2003). F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell 115(2): 163-75. 14567914

Hu, Y., Ye, Y. and Fortini, M. E. (2002). Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2: 69-78. 11782315

Hubbard, E. J., et al. (1997). sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 11(23): 3182-93.

Huppert, S. S., Jacobsen, T. L. and Muskavitch, M. A. (1997). Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. Development 124(17): 3283-3291.

Huppert, S. S., et al. (2000). Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405(6789): 966-70.

Huppert, S. S., Ilagan, M. X., De Strooper, B. and Kopan, R. (2005). Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev. Cell 8(5): 677-88. 15866159

Hukriede, N. A., Gu, Y. and Fleming, R. J. (1997). A dominant-negative form of Serrate acts as a general antagonist of Notch activation. Development 124(17): 3427-3437.

Hwang, B. J., Meruelo, A. D. and Sternberg, P. W. (2007). C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion. Development 134: 669-679. Medline abstract: 17215301

Ikeya, T. and Hayashi, S. (1999). Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea. Development 126: 4455-4463.

Imai, K. S., Satoh, N. and Satou, Y. (2002). An essential role of a FoxD gene in notochord induction in Ciona embryos. Development 129: 3441-3453. 12091314

Ishikawa, H. O, et al. (2005). Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. Proc. Natl. Acad. Sci. 102(51): 18532-7. 16344471

Islam, R., Wei, S. Y., Chiu, W. H., Hortsch, M. and Hsu, J. C. (2003). Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway. Development. 130(10): 2051-9. 12668620

Itoh, M., et al. (2003). Mind bomb is a ubiquitin ligase that is essential for efficient activation of notch signaling by Delta. Dev. Cell 4: 67-82. 12530964

Iwaki, D. D. and Lengyel, J. A. (2002). A Delta-Notch signaling border regulated by Engrailed/Invected repression specifies boundary cells in the Drosophila hindgut. Mech. Dev. 114: 71-84. 12175491

Jack, J.W., Dorsett, D., Delotto, Y. and Liu, S. (1991). Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer. Development 113: 735-747

Jackson, S. M. and Blochlinger, K. (1997). cut interacts with Notch and protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis. Development 124: 3663-3672.

Jacobsen, T. L., et al. (1998). Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila. Development 125(22): 4531-4540

Jaekel, R. and Klein, T. (2006). The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking, Dev. Cell 11: 655-669. Medline abstract: 17084358

Jarriault, S., et al. (1995). Signalling downstream of activated mammalian Notch. Nature 377: 355-358

Jarriault, S., et al. (1998). Delta-1 activation of Notch-1 signaling results in HES-1 transactivation. Mol. Cell. Biol. 18(12): 7423-7431.

Jarriault, S. and Greenwald, I. (2002). Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans Genes Dev. 16: 2713-2728. 12381669

Jarriault, S. and Greenwald, I. (2005). Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. Dev. Biol. 287(1): 1-10. 16197940

Jékely, G. and Rørth, P. (2003). Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO reports 4: 1163-1168. 14608370

Jennings, B. , Preiss, A., Delidakis, C. and Bray, S. (1994). The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development 120: 3537-3548

Johnson, E., Wayne, S. and Nagoshi, R. (1995). fs(1)Yb is required for ovary follicle cell differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genes. Genetics 140: 207-217

Johnston, L. A. and Edgar, B. A. (1998). Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 394(6688): 82-84.

Jordan, K. C., et al. (2000). The homeobox gene mirror links EGF signaling to embryonic dorso-ventral axis formation through Notch activation. Nat. Genet. 24(4): 429-33.

Joshi, M., Buchanan, K. T., Shroff, S. and Orenic, T. V. (2006). Delta and Hairy establish a periodic prepattern that positions sensory bristles in Drosophila legs. Dev. Biol. 293(1): 64-76. 16542648

Ju, B.-G., et al. (2000). Fringe forms a complex with Notch. Nature 405: 191-195.

Julich, D., et al. (2005). Integrinalpha5 and Delta/Notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis. Dev. Cell 8(4): 575-86. 15809039

Justice, N., Roegiers, F. Jan, L. Y., and Jan, Y. H. (2003). Lethal giant larvae acts together with Numb in Notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr. Biol. 13: 778-783. 12725738

Kato, H., et al. (1997). Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development 124(20): 4133-4141.

Kenyon, K. L., Ranade, S. S., Curtiss, J. Mlodzik, M. and Pignoni, F. (2003). Coordinating proliferation and tissue specification to promote regional identity in the Drosophila head. Dev. Cell 5: 403-414. 12967560

Kerber, B., et al. (2001). The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development. Development 128(8): 1231-8. 11262225

Kidd, S., Kelley, M.R. and Young, M.W. (1986). Sequence of the Notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Molec. Cell. Biol. 6: 3094-3108

Kidd, S., Lieber, T. and Young, M. W. (1998). Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev. 23: 3728-3740.

Kidd, S., et al. (2002). Furin cleavage is not a requirement for Drosophila Notch function. Mech. Dev. 115: 41-51. 12049766

Kim, J., et al. (1996). Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382: 133-138

Klein, T., Brennan, K. and Arias, A. M. (1997). An intrinsic dominant negative activity of Serrate that is modulated during wing development in Drosophila. Dev. Biol. 189(1): 123-134

Klein, T. and Martinez Arias, A. (1998). Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development. Development 125(15): 2951-2962.

Klein, T. and Martinez Arias, A. (1999). The Vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila. Development 126: 913-925.

Klein, T., et al. (2000). Two different activities of Suppressor of Hairless during wing development in Drosophila. Development 127: 3553-3566

Klein, T., et al. (2003). The tumor suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development. Dev. Bio. 255: 313-333. 12648493

Klueg, K. M., Parody, T. R. and Muskavitch, M. A. T. (1998). Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development. Mol. Biol. Cell 9(7): 1709-1723.

Klueg, K. M. and Muskavitch, M. A. T. (1999). Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila. J. of Cell Sci. 112: 3289-3297.

Kooh, P.J., Fehon, R.G. and Muskavitch, M.A. (1993). Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development 117: 493-507

Koizumi, K-i., et al. (2001). The role of presenilin 1 during somite segmentation Development 128: 1391-1402. 11262239

Konsolaki, M., and T. Schupbach. 1998. windbeutel, a gene required for dorsoventral patterning in Drosophila, encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum. Genes Dev. 12: 120-13.

Kopan, R., Nye, J. S. and Weintraub, H. (1994). The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed by the basic helix-loop-helix region of MyoD. Development 120: 2385-2396

Kortschak, R. D., Tamme, R. and Lardelli, M. (2001). Evolutionary analysis of vertebrate Notch genes. Dev. Genes Evol. 211: 350-354. 11466531

Krebs, L. T., et al. (2000). Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 14: 1343-1352.

Krebs, L. T., et al. (2001). The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. Dev. Bio. 238: 110-119

Krejcí, A. and Bray, S. (2007). Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev. 21(11): 1322-7. PubMed citation: 17545467

Kubu, C. J., et al. (2002). Developmental changes in Notch1 and Numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Dev. Biol. 244: 199-214. 11900468

Kubo, F., Takeichi, M. and Nakagawa, S. (2005). Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes. Development 132(12): 2759-70. 15901663

Kumar, J. P. and Moses, K. (2001). EGF receptor and Notch signaling act upstream of Eyeless/Pax6 to control eye specification. Cell 104: 687-697. 11257223

Kurata, S., et al. (2000). Notch signaling and the determination of appendage identity. Proc. Natl. Acad. Sci. 97: 2117-2122.

Kurooka, H., Honjo, T. (2000). Functional interaction between the mouse Notch 1 intracellular region and histone acetyltransferases PCAF and GCN5. J. Biol. Chem. 275, 17211-17220. 10747963

Lamar, E., et al. (2001). Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev. 15: 1885-1899. 11485984

Lammel, U. and Saumweber, H. (2000). X-linked loci of Drosophila melanogaster causing defects in the morphology of the embryonic salivary glands. Dev. Genes Evol. (2000) 210: 525-535

Lamont, L. B., et al. (2004). FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline. Dev. Cell 7: 697-707. 15525531

Lanford, P. J., et al. (1999). Notch signalling pathway mediates hair cell development in mammalian cochlea. Nat. Genet. 21(3): 289-92.

Larsson, C. (1994). The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation. Genomics 24: 253-258

Lardelli, M., Dahlstrand, J. and Lendahl, U. (1994). The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech. Dev. 46: 123-136

Lardelli, M., et al. (1997). Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development. Mech. Dev. 59(2): 177-190.

Larkin, M. K., et al. (1996). Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte. Development 122, 3639-3650

Larkin, M. K., et al. (1999). Role of Notch pathway in terminal follicle cell differentiation during Drosophila oogenesis. Dev. Genes Evol. 209: 301-311

Lauring, A. S. and Overbaugh, J. (2000). Evidence that an IRES within the Notch2 coding region can direct expression of a nuclear form of the protein. Mol. Cell 6: 939-945

Lawrence, N., et al. (2000). Structural requirements for Notch signaling with Delta and Serrate during the development and patterning of the wing disc of Drosophila. Development 127: 3185-3195.

Lawrence, N., et al. (2001). Notch signaling targets the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila. Curr. Biol. 11: 375-385. 11301248

Lawson, N. D., et al. (2001). Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development 128: 3675-3683. 11585794

Lawson, N. D., Vogel, A. M. and Weinstein, B. M. (2002). sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev. Cell 3: 127-136. 12110173

Lecourtois, M. and Schweisguth, F. (1998). Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos. Curr. Biol. 8(13): 771-4.

Lee, E. C. and Baker, N. E. (1996). gp300sca is not a high affinity Notch ligand. Biochem. Biophys. Res. Commun. 225(3): 720-5.

Lee, E. C., Yu, S. Y. and Baker, N. E. (2000). The scabrous protein can act as an extracellular antagonist of notch signaling in the Drosophila wing. Curr. Biol. 10(15): 931-4.

Lee, J., Basak, J. M., Demehri, S. and Kopan, R. (2007). Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development 134(15): 2795-806. Medline abstract: 17611229

Lei, L., Xu, A., Panin, V. M. and Irvine, K. D. (2003). An O-fucose site in the ligand binding domain inhibits Notch activation. Development 130: 6411-6421. Medline abstract: 14627724

Levine, B., et al. (2007). Notch signaling links interactions between the C/EBP homolog slow border cells and the GILZ homolog bunched during cell migration. Dev. Biol. 305: 217-231. PubMed citation: 17383627

Levitan, D. and Greenwald, I. (1995). Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377(6547): 351-4.

Levitan, D. and Greenwald, I. (1998a). LIN-12 protein expression and localization during vulval development in C. elegans. Development 125(16): 3101-3109.

Levitan, D. and Greenwald, I. (1998b). Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Development 125(18): 3599-3606.

Levitan, D., et al. (2001). APH-2/Nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad. Dev. Biol. 240(2): 654-61. 11784090

Lewis, A. K., et al. (1998). Distinct expression patterns of Notch family receptors and ligands during development of the mammalian inner ear. Mech. Dev. 78(1-2): 159-163.

Li, L., Krantz, I. D., Deng, Y., Genin, A., Banta, A. B., Collins, C. C., Qi, M., Trask, B. J., Kuo, W. L. and Cochran, J., et al. (1997). Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat. Genet. 16: 243-251. 9207788

Li, Y., Li, L., Irvine, K. D. and Baker, N. E. (2003). Notch activity in neural cells triggered by a mutant allele with altered glycosylation. Development 130: 2829-2840. 12756168

Li, Y. and Baker, N. E. (2004). The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila. BMC Dev. Biol.4: 5. 15113404

Li, X. and Greenwald, I. (1997). HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Natl. Acad. Sci. 94(22): 12204-12209.

Li, Y. and Baker, N. E. (2001). Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye Curr. Biol. 11: 330-338. 11267869

Li, Y., Fetchko, M., Lai, Z. C. and Baker, N. E. (2003). Scabrous and Gp150 are endosomal proteins that regulate Notch activity. Development 130: 2819-2827. 12756167

Lieber, T, et al. (1993). Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev 7: 1949-65

Lieber, T., Kidd, S. and Young, M. W. (2002). kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev. 16: 209-221. 11799064

Ligoxygakis, P., et al. (1998). A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex. Development 125(15): 2893-2900.

Lin, M.-H., et al. (2000). Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development 127: 2421-2432

Liu, Y., et al. (2007). Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development 134(6): 1111-22. Medline abstract: 17287248

Llimargas, M. (1999). The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates. Development 126: 2355-2364.

Logeat, F., et al. (1998). The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc. Natl. Acad. Sci. 95(14): 8108-8112.

López, S. L., et al. (2003). Notch activates sonic hedgehog and both are involved in the specification of dorsal midline cell-fates in Xenopus. Development 130: 2225-2238. 12668635

Lopez, S. L., et al. (2005). The Notch-target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos. Development 132(5): 1035-46.15689375

López-Schier, H. and Johnston. D. St. (2001). Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis. Genes Dev. 15: 1393-1405. 11390359

López-Schier, H. and St Johnston, D. (2002). Drosophila Nicastrin is essential for the intramembranous cleavage of Notch. Dev. Cell 2: 79-89. 11782316

Lorent, K., et al. (2004). Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy. Development 131: 5753-5766. 15509774

Lu, F. M. and Lux, S. E. (1996). Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. Proc. Natl. Acad. Sci. 93: 5663-67

Luke T. Krebs, L. T., et al. (2003). Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 17: 1207-1212. 12730124

Lundell, M. J., et al. (2003). The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila. Development 130: 4109-4121. 12874131

Lütolf, S., et al. (2002). Notch1 is required for neuronal and glial differentiation in the cerebellum. Development 129: 373-385. 11807030

Luo, B., et al. (1997). Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol. Cell. Biol. 17(10): 6057-6067.

Lyman, D. F. and Yedvobnick, B. (1995). Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development. Genetics 141: 1491-1505

References continued: part 3/3 | back to part 1/3

Notch continued: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

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