Interactive Fly, Drosophila

frizzled


REFERENCES

Adler, P.N., Vinson, C., Park, W.J., Conover, S. and Klein, L. (1990). Molecular structure of frizzled, a Drosophila tissue polarity gene. Genetics 126: 401-416

Adler, P., Charlton, J. and Liu, J. (1998). Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling. Development 125(5): 959-968.

Adler, P. N., Taylor, J. and Charlton, J. (2000). The domineering non-autonomy of frizzled and Van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling. Mech. Dev. 96: 197-207.

Adler, P. N. (2002). Planar signaling and morphogenesis in Drosophila. Dev. Cell 2: 525-535. 12015961

Amonlirdviman, K., et al. (2005). Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Science 307: 423-426. 15662015

Axelrod, J. D., et al. (1998). Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev. 12(16): 2610-2622.

Axelrod, J. D. (2001). Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev. 15: 1182-1187. 11358862

Bellaïche, Y., et al. (2001). The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell 106: 355-366. 11509184

Bhanot, P, et al. (1996). A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382: 225-230

Bhat, K. M. (1998). frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to Wingless in neurogenesis. Cell 95: 1027-1036.

Bastock, R. and Strutt, D. (2007). The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis. Development 134(17): 3055-64. PubMed citation; Online text

Boutros, M., Mihaly, J., Bouwmeester, T. and Mlodzik, M. (2000). Signaling specificity by Frizzled receptors in Drosophila. Science 288(5472): 1825-8.

Chae, J., et al. (1999). The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family. Development 126(23): 5421-9.

Chan, S.D. et al. (1992). Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. J. Bio. Chem. 267: 25202-25207

Chanut, F. and Heberlein, V. (1995). Role of the morphogenetic furrow in establishing polarity in the Drosophila eye. Development 121: 4085-94

Chen, C.-m. and Struhl, G. (1999). Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila. Development 126: 5441-5452.

Classen, A.-K., Anderson, K. I., Marois, E. and Eaton, S. (2005). Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev. Cell 9(6): 805-17. 16326392

Cong, F., Schweizer, L. and Varmus, H. (2004). Wnt signals across the plasma membrane to activate the þ-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131: 5103-5115. 15459103

Clandinin, T. R. and Zipursky, S. L. (2000). Afferent growth cone interactions control synaptic specificity in the Drosophila visual system. Neuron 28: 427-436.

Collier, S. and Gubb, D. (1997). Drosophila tissue polarity requires the cell-autonomous activity of the fuzzy gene, which encodes a novel transmembrane protein. Development 124(20): 4029-4037.

Cooper, M. T. and Bray, S. J. (1999). Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Nature 397(6719): 526-30.

Das, G., Reynolds-Kenneally, J. and Mlodzik, M. (2002). The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye. Dev. Cell 2: 655-666. 12015972

Deardorff, M. A., et al. (1998). Frizzled-8 is expressed in the spemann organizer and plays a role in early morphogenesis. Development 125(14): 2687-2700.

del Alamo, D. and Mlodzik, M. (2006). Frizzled/PCP-dependent asymmetric Neuralized expression determines R3/R4 Fates in the Drosophila eye. Dev. Cell 11: 887-894. Medline abstract: 17141162

Djiane, A., Yogev, S. and Mlodzik, M. (2005). The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye. Cell 121: 621-631. 15907474

Fanto, M., Mayes, C. A. and Mlodzik, M. (1998). Linking cell-fate specification to planar polarity: determination of the R3/R4 photoreceptors is a prerequisite for the interpretation of the Frizzled mediated polarity signal. Mech. Dev. 74(1-2): 51-58

Fanto, M. and Mlodzik, M. (1999). Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature 397(6719): 523-6.

Feiguin, F., Hannus, M., Mlodzik, M. and Eaton, S. (2001). The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Dev. Cell 1: 93-101

Fire, A., Xu, S., Montgomery, M., Kostas, S.A., Driver, S.E., and Mello, C.C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.

Garoia, F., et al. (2000). Cell behaviour of Drosophila fat cadherin mutations in wing development. Mech. Dev. 94: 95-109. 10842062

Gho, M. and Schweisguth, F. (1998). Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila. Nature 393(6681): 178-81.

Gomperts, S. N. (1996). Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family. Cell 84: 659-662

Gubb, D. and A. Garcia-Bellido. 1982. A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster. J. Embryol. Exp. Morphol. 68: 37-57

Gubb, D., et al. (1999). The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Genes Dev. 13(17): 2315-27.

Han, C., et al. (2005). Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Development 132: 667-679. 15647319

Harris, K. E. and Beckendorf, S. K. (2007). Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development 134(11): 2017-25. Medline abstract: 17507403

Heberlein, U., Borod, E. R. and Chanut, F. A. (1998). Dorsoventral patterning in the Drosophila retina by wingless. 125(4): 567-577.

Jarman, A.P. (1996). Epithelial polarity in the Drosophila compound eye: eyes left or right. Trends in Genetics 12: 121-123

Klingensmith, J., Nusse R., and Perrimon, N. (1994). The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev 8: 118-30

Jones, K.H., Liu, J. and Adler, P.N. (1996). Molecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster. Genetics 142: 205-215

Katanaev, V. L., Ponzielli, R., Semeriva, M. and Tomlinson, A. (2005). Trimeric G protein-dependent Frizzled signaling in Drosophila. Cell 120: 111-122. 15652486

Katanaev, V. L., Tomlinson, A. (2006). Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. Proc. Natl. Acad. Sci. 103: 6524-6529. 16617104

Kennerdell, J. R. and Carthew, R. W. (1998). Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway. Cell 95: 1017-1026.

Klein, T. J., Jenny, A., Djiane, A. and Mlodzik, M. (2006). CKIε/discs overgrown promotes both Wnt-Fz/β-catenin and Fz/PCP signaling in Drosophila. Curr. Biol. 16(13): 1337-43. 16824922

Krasnow, R.E. and Adler, P.N. (1994). A single frizzled protein has a dual function on tissue polarity. Development 120: 1883-1893

Krasnow, R. E., Wong, L.L. and Adler, P. N. (1995). dishevelled is a component of the frizzled signaling pathway in Drosophila. Development 121:4095-4102

Lawrence, P. A., Casal, J. and Struhl, G. (2004). Cell interactions and planar polarity in the abdominal epidermis of Drosophila. Development 131: 4651-4664. 15329345

Lecourtois, M., et al. (2001). Wingless capture by Frizzled and Frizzled2 in Drosophila embryos. Dev. Bio. 235: 467-475. 11437451

Lee, H. and Adler, P. N. (2002). The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy. Genetics 160: 1535-1547. 11973308

Mayr, T., et al. (1997). Fritz: a secreted frizzled-related protein that inhibits Wnt activity. Mech. Dev. 63 (1): 109-125.

Moline, M. M., Dierick, H. A., Southern, C. and Bejsovec, A. (2000). Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic Wingless signal transduction. Curr. Biol. 10: 1127-1130. 10996794

Park, W.J., Liu, J. and Adler, P.N. (1994). The frizzled gene of Drosophila encodes a membrane protein with an odd number of transmembrane domains. Mech Dev. 45: 127-137

Povelones, M., Howes, R., Fish, M. and Nusse, R. (2005a). Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism. Genetics 171(4): 1643-54. 16085697

Povelones, M. and Nusse, R. (2005b). The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling. EMBO J. 24(19): 3493-503. 16163385

Price, M. H., et al. (2006). Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle. J. Cell Sci. 119: 403-415. 16418222

Rasmussen, J. T., et al. (2001). Regulation of eye development by frizzled signaling in Xenopus. Proc. Natl. Acad. Sci. Vol. 98: 3861-3866. 11274406

Rehn, M. and Pihlajaniemi, T. (1995). Identification of three N terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins. J.Biol. Chem. 270: 4705-11

Reifegerste, R., Ma, C. and Moses, K. (1997). A polarity field is established early in the development of the Drosophila compound eye. Mech. Dev. 68(1-2): 69-79.

Roegiers, F., et al. (2001). Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage. Nature Cell Bio. 3: 58-67 . 11146627

Rothbacher, U., et al. (2000). Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J. 19: 1010-1022.

Sawa, H., Lobel, L., and Horvitz, H. R. (1996). The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Genes Dev 10 (17): 2189-2197.

Schlesinger, A., et al. (1999). Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev. 13: 2028-2038.

Shi, D. L., Goisset, C. and Boucaut, J. C. (1998). Expression of Xfz3, a Xenopus frizzled family member, is restricted to the early nervous system. Mech. Dev. 70: 35-47.

Shimada, Y., et al. (2001). Asymmetric colocalization of Flamingo, a seven-pass transmembrane cadherin, and Dishevelled in planar cell polarization. Cur. Biol. 11: 859-863. 11516647

Shimada, Y., Yonemura, S., Ohkura, H., Strutt, D. and Uemura, T. (2006). Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. Dev. Cell 10(2): 209-22. 16459300

Shulman, J. M., Perrimon, N. and Axelrod, J. D. (1998). Frizzled signaling and the developmental control of cell polarity. Trends Genet. 14: 452-458.

Sotillos, S., et al. (2004). DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J. Cell Biol. 166: 549-557. 15302858

Srahna, M., Leyssen, M., Choi, C. M., Fradkin, L. G., Noordermeer, J. N. and Hassan, B. A. (2006). A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 4(11): e348. Medline abstract: 17032066

Strapps, W. R. and Tomlinson, A. (2001). Transducing properties of Drosophila Frizzled proteins. Development 128: 4829-4835. 11731462

Strutt, D. I., Weber. U., and Mlodzik, M. (1997). The role of RhoA in tissue polarity and Frizzled signalling. Nature 387 (6630): 292-295.

Strutt, D. I. (2001). Asymmetric localization of Frizzled and the establishment of cell polarity in the Drosophila wing. Molec. Cell 367-375. 11239465

Strutt, H. and Strutt, D. (2002). Nonautonomous planar polarity patterning in Drosophila: Dishevelled-independent functions of Frizzled. Dev. Cell 3: 851-863. 12479810

Strutt, D., Johnson, R., Cooper, K. and Bray, S. (2002). Asymmetric localization of Frizzled and the determination of Notch-dependent cell fate in the Drosophila eye. Curr. Biol. 12: 813-824. 12015117

Strutt, H. and Strutt, D. (2003). EGF signaling and ommatidial rotation in the Drosophila eye. Curr. Biol. 13: 1451-1457. 12932331

Taylor J., et al. (1998). Van Gogh: A new Drosophila tissue polarity gene. Genetics 150(1): 199-210.

Tomlinson, A., Strapps, W. R. and Heemskerk, J. (1997). Linking Frizzled and Wnt signaling in Drosophila development. Development 124(22): 4515-4521.

Tomlinson, A. and Struhl, G. (1999). Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye. Development 126: 5725-5738

Tree, D. R. P., et al. (2002). Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell 109: 371-381. 12015986

Turner, C. M. and Adler, P. N. (1998). Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in Drosophila. Mech. Dev. 70: 181-192.

Usui, T., et al. (1999). Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell 98(5): 585-95.

Wagner, U., et al. (1997). Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells. FEBS Lett. 411: 369-372

Wang, Y., et al. (1996). A large family of putative receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J. Biol. Chem. 271: 4468-76

Weber, U., Paricio, N. and Mlodzik, M. (2000). Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 127: 3619-3629

Wolff, T. and Rubin, G. M. (1998). Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila. Development 125(6): 1149-1159.

Wong, L. L. and Adler, P. N. (1993). Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells. J. Cell Biol. 123: 209-221.

Wu, J., Klein, T. J. and Mlodzik, M. (2004). Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol. 2: e158. 15252441

Yang, C.-h., Axelrod, J. D. and Simon, M. A. (2002). Regulation of Frizzled by Fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108: 675-688. 11893338

Zhang, J. and Carthew, R. W. (1998). Interactions between Wingless and DFz2 during Drosophila wing development. Development 125(16): 3075-3085.

Zhao, Z., Lee, C., Baldini, A. and Caskey, C.T. (1995). A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1. Genomics 27: 370-373

Zheng,, L., Zhang, J. and Carthew, R.W. (1995). frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. Development 121: 3045-3055


frizzled: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 10 March 2008



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