Enhancer of split

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Giebel, B., et al. (1999). The Notch signaling pathway is required to specify muscle progenitor cells in Drosophila. Mech. Dev. 86: 137-145

Gigliani, F., et al. (1996). Interactions among the bHLH domains of the proteins encoded by the Enhancer of split and achaete-scute gene complexes in Drosophila. Mol. Gen. Genet. 251: 628-634

Gratton, M.-O. et al. (2003). Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. Mol. Cell. Biol. 23: 6922-6935. Medline abstract: 12972610

Heitzler, P., et al. (1996). Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development 122: 161-171

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Ishibashi, M., et al. (1995). Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis and severe neural tube defects. Genes and Dev 9: 3136-3148

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Janody, F. and Treisman, J. E. (2011). Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Dev. Dyn. 240(9): 2051-9. PubMed Citation: 21793099

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Jimenez, G. and Ish-Horowicz, D. (1997). A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression. Mol. Cell. Biol. 17: 4355-4362

Kahali, B., Bose, A., Karandikar, U., Bishop, C. P. and Bidwai, A. (2009). On the mechanism underlying the divergent retinal and bristle defects of M8* (E(spl)D) in Drosophila. Genesis 47(7): 456-68. PubMed Citation: 19415625

Karandikar, U., et al. (2004). Drosophila CK2 regulates eye morphogenesis via phosphorylation of E(spl)M8. Mech. Dev. 121: 273-286. Medline abstract: 15003630

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Kramatschek, B. and Campos-Ortega, J. A. (1994). Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes. Development 120: 815-826

Kugler, S. J. and Nagel, A. C. (2010). A novel Pzg-NURF complex regulates Notch target gene activity. Mol. Biol. Cell 21(19): 3443-8. PubMed Citation: 20685964

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Liang, Z. and Biggin, M. D. (1998). Eve and Ftz regulate a wide array of genes in blastoderm embryos: the selector homeoproteins directly or indirectly regulate most genes in Drosophila. Development 125(22): 4471-4482

Ligoxygakis, P., et al. (1998). A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex. Development 125(15): 2893-2900

Ligoxygakis, P., et al. (1999). Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila. Development 126: 2205-2214

Lim, J., Jafar-Nejad, H., Hsu, Y. C. and Choi, K. W. (2008). Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. EMBO Rep. 9(11): 1128-33. PubMed Citation: 18758436

Lobe, C. G. (1997). Expression of the helix-loop-helix factor, Hes3, during embryo development suggests a role in early midbrain-hindbrain patterning. Mech. Dev. 62 (2): 227-237

Majumdar, A., Nagaraj, R. and Banerjee, U. (1997). strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin in Drosophila. Genes Dev. 11: 1341-1353

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Müller, M., Weizsäcker, E. v. and Campos-Ortega, J. A. (1996). Transcription of a zebrafish gene of the hairy-Enhancer of split family delineates the midbrain anlage in the neural plate. Dev. Genes Evol. 206: 153-160

Nagel, A. C. and Preiss, A. (1999). Notch^spl Is deficient for inductive processes in the Eye, and E(spl)^D Enhances split by interfering with proneural activity. Dev. Biol. 208(2): 406-415.

Nakayama, H., et al. (1997). Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev. Genet. 21(1): 21-30

Nègre, N., Ghysen, A. and Martinez, A. M. (2003). Mitotic G2-arrest is required for neural cell fate determination in Drosophila. Mech. Dev. 120: 253-265. 12559497

Nellesen, D. T., Lai, E. C. and Posakony, J. W. (1999). Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev. Biol. 213(1): 33-53. PubMed Citation: 10452845

Nicholson, S. C., Nicolay, B. N., Frolov, M. V. and Moberg, K. H. (2011). Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development 138(2): 251-60. PubMed Citation: 21148181

Nolo, R., Abbott, L. A. and Bellen, H. J. (2000), Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell. 102(3): 349-62. 10975525

Oellers, N., Dehio, M. and Knust, E. (1994). bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol Gen Genet 244: 465-473

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Rohrbaugh, M., et al. (2002). Notch activation of yan expression is antagonized by RTK/Pointed signaling in the Drosophila eye. Curr. Biol. 12: 576-581. 11937027

Rossner, M. J., et al. (1998). SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol. Cell. Neurosci. 10(3-4): 460-75

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Singson, A., et al. (1994). Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev. 8: 2058-71

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Takke, C., et al. (1999a). her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of notch signalling. Development 126(9): 1811-1821

Takke, C. and Campos-Ortega, J. A. (1999b). her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development. Development 126, 3005-3014

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Wurmbach, E., Wech, I. and Preiss, A. (1999). The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes. Mech. Dev. 80(2): 171-80

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zur Lage, P., Jan, Y. N. and Jarman, A. P. (1997). Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters. Curr. Biol. 7: 166-175

zur Lage, P. and Jarman, A. P. (1999). Antagonism of EGFR and Notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors. Development 126: 3149-3157

date revised: 5 August 2011