Enhancer of split

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Cooper, M. T. D., et al. (2000a). Spatially restricted factors cooperate with Notch in the regulation of Enhancer of split genes. Dev. Biol. 221: 390-403

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Eastman, D. S., et al. (1997). Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression. Mol. Cell. Biol. 17(9): 5620-5628.

Escudero, L. M., et al. (2003). Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Development 130: 6305-6316. 14623820

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Giagtzoglou, N., et al. (2003). Two modes of recruitment of E(spl) repressors onto target genes. Development 130: 259-270. Medline abstract: 12466194

Giebel, B. and Campos-Ortega, J. A. (1997). Functional dissection of the Drosophila Enhancer of split protein, a suppressor of neurogenesis. Proc. Natl. Acad. Sci. 94 (12): 6250-6254. 9177203

Giebel, B., et al. (1999). The Notch signaling pathway is required to specify muscle progenitor cells in Drosophila. Mech. Dev. 86: 137-145

Gigliani, F., et al. (1996). Interactions among the bHLH domains of the proteins encoded by the Enhancer of split and achaete-scute gene complexes in Drosophila. Mol. Gen. Genet. 251: 628-634

Gratton, M.-O. et al. (2003). Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. Mol. Cell. Biol. 23: 6922-6935. Medline abstract: 12972610

Heitzler, P., et al. (1996). Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development 122: 161-171

Huang, A. M., Rusch, J., and Levine, M. (1997). An anteroposterior Dorsal gradient in the Drosophila embryo. Genes Dev. 11(15): 1963-1973.

Ishibashi, M., et al. (1995). Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis and severe neural tube defects. Genes and Dev 9: 3136-3148

Jafar-Nejad, H., et al. (2003). Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 17: 2966-2978. 14665671

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Jarreault, S., et al. (1995). Signaling downstream of activated mammalian Notch. Nature 377: 355-358

Jennings, B., et al. (1995). Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins. Development 121: 3745-52

Jimenez, G. and Ish-Horowicz, D. (1997). A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression. Mol. Cell. Biol. 17: 4355-4362.

Karandikar, U., et al. (2004). Drosophila CK2 regulates eye morphogenesis via phosphorylation of E(spl)M8. Mech. Dev. 121: 273-286. Medline abstract: 15003630

Knust, E., Tietz, K. and Campos-Ortega, J. A. (1987). Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster.EMBO J. 6: 4113-4123

Koelzer, S. and Klein, T. (2003). A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development 130: 1973-1988. 12642500

Kramatschek, B. and Campos-Ortega, J. A. (1994). Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes. Development 120: 815-826

Lai, E. C., Burks, C. and Posakony, J. W. (1998a). The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts. Development 125(20): 4077-88.

Lai, E. C. and Posakony, J. W. (1998b). Regulation of Drosophila neurogenesis byRNA:RNA duplexes? Cell 93: 1103-1104

Lai, E. C. (2002). Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat. Genet. 30(4): 363-4. 11896390

Lecourtois, M. and Schweisguth, F. (1995). The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split Complex genes triggered by Notch signaling. Genes and Dev. 9:2598-2608.

Lesokhin, A. M., et al. (1999). Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila. Dev. Biol. 205(1): 129-44.

Liang, Z. and Biggin, M. D. (1998). Eve and Ftz regulate a wide array of genes in blastoderm embryos: the selector homeoproteins directly or indirectly regulate most genes in Drosophila. Development 125(22): 4471-4482

Ligoxygakis, P., et al. (1998). A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex. Development 125(15): 2893-2900.

Ligoxygakis, P., et al. (1999). Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila. Development 126: 2205-2214

Lobe, C. G. (1997). Expression of the helix-loop-helix factor, Hes3, during embryo development suggests a role in early midbrain-hindbrain patterning. Mech. Dev. 62 (2): 227-237.

Majumdar, A., Nagaraj, R. and Banerjee, U. (1997). strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin in Drosophila. Genes Dev. 11: 1341-1353

Meir, E., et al. (2002). Robustness, flexibility, and the role of lateral inhibition in the neurogenic network. Curr. Biol. 12: 778-786. 12015114

Müller, M., Weizsäcker, E. v. and Campos-Ortega, J. A. (1996). Transcription of a zebrafish gene of the hairy-Enhancer of split family delineates the midbrain anlage in the neural plate. Dev. Genes Evol. 206: 153-160

Nagel, A. C. and Preiss, A. (1999). Notch^spl Is deficient for inductive processes in the Eye, and E(spl)^D Enhances split by interfering with proneural activity. Dev. Biol. 208(2): 406-415.

Nakayama, H., et al. (1997). Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev. Genet. 21(1): 21-30.

Nègre, N., Ghysen, A. and Martinez, A. M. (2003). Mitotic G2-arrest is required for neural cell fate determination in Drosophila. Mech. Dev. 120: 253-265. 12559497

Nellesen, D. T., Lai, E. C. and Posakony, J. W. (1999). Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev. Biol. 213(1): 33-53.

Nolo, R., Abbott, L. A. and Bellen, H. J. (2000), Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell. 102(3): 349-62. 10975525

Oellers, N., Dehio, M. and Knust, E. (1994). bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol Gen Genet 244: 465-473

Pineda, D., et al. (2002). The genetic network of prototypic planarian eye regeneration is Pax6 independent. Development 129: 1423-1434. 11880351

Powell, P. A., et al. (2001). Scabrous complexes with Notch to mediate boundary formation. Nature 409: 626-630. 11214322

Rohrbaugh, M., et al. (2002). Notch activation of yan expression is antagonized by RTK/Pointed signaling in the Drosophila eye. Curr. Biol. 12: 576-581. 11937027

Rossner, M. J., et al. (1998). SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol. Cell. Neurosci. 10(3-4): 460-75.

Seugnet, L., Simpson, P. and Haenlin, M. (1997a). Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila. Development 124: 2015-2025.

Singson, A., et al. (1994). Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev. 8: 2058-71

Strom, A., et al. (1997). Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation. Genes Dev. 11(23): 3168-3181.

Takakayashi, K., et al. (1994). Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. J. Biol Chem 269: 5150-56

Takke, C., et al. (1999a). her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of notch signalling. Development 126(9): 1811-1821

Takke, C. and Campos-Ortega, J. A. (1999b). her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development. Development 126, 3005-3014.

Tata, F., and Hartley, D. A. (1995). Inhibition of cell fate in Drosophila by Enhancer of split genes. Mech. Dev. 51: 305-315

Tomita, K., et al. (1996). Mammalian hairy and Enhancer of split homolog 1 regulates differentiation of retinal neurons and is essential for eye morphogenesis. Neuron 16: 723-734.

Tun, T., et al. (1994). Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res 22: 965-971

Welshons, W.J. (1956). Dosage experiments with split mutations in the presense of an enhancer of split. Drosophila Inform. Serv. 30: 157-158

Wurmbach, E., Wech, I. and Preiss, A. (1999). The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes. Mech. Dev. 80(2): 171-80.

Younossi-Hartenstein, A., et al. (1996). Early neurogenesis of the Drosophila brain. J. Comp. Neur. 370: 313-329

zur Lage, P., Jan, Y. N. and Jarman, A. P. (1997). Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters. Curr. Biol. 7: 166-175.

zur Lage, P. and Jarman, A. P. (1999). Antagonism of EGFR and Notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors. Development 126: 3149-3157

date revised: 20 March 2007