dunce

Barad, M., et al. (1998). Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc. Natl. Acad. Sci. 95(25): 15020-5.

Bellen, H. J., et al. (1987). Two Drosophila learning mutants, dunce and rutabaga, provide evidence of a maternal role for cAMP on embryogenesis. Dev. Biol. 121: 432-44

Berke, B and Wu, C. F. (2002). Regional calcium regulation within cultured Drosophila neurons: Effects of altered cAMP metabolism by the learning mutations dunce and rutabaga. J. Neurosci. 22(11): 4437-4447. 12040051

Bhattacharya, A., Gu, G.G., Singh, S. (1999). Modulation of dihydropyridine-sensitive calcium channels in Drosophila by a cAMP-mediated pathway. J. Neurobiol. 39(4): 491-500.

Bolger, G. B., Rodgers, L. and Riggs, M. (1994). Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. Gene 149: 237-44.

Bolger, G., et al. (1993). A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol. Cell. Biol. 13: 6558-71.

Chen, C. N., Denome, S. and Davis, R. L. (1989). Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase. Proc. Natl. Acad. Sci. 83: 9313-7

Cherry, J. A. and Davis, R. L. (1995). A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons. J. Neurobiol. 28: 102-113

Cherry, J. A. and Davis, R. L. (1999). Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect. J. Comp. Neurol. 407(2): 287-301.

Dauwalder, B. and Davis, R. L. (1995). Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes. J. Neurosci. 15: 3490-3499

Davis, R. L., et al. (1995). The cyclic AMP system and Drosophila learning. Mol. Cell. Biochem. 149-150: 271-278

Davis, G. W., Schuster, C. M. and Goodman, C. S. (1996). Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron 17: 669-679

Davis, R. L., et al. (1996). Physiology and biochemistry of Drosophila learning mutants. Physiol. Rev. 76: 299-317 A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce. Proc. Natl. Acad. Sci. 88: 557-60

Delgado, R., et al. (1991). A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce. Proc. Natl. Acad. Sci 88: 557-560

Delgado, R., et al. (1998). Outward currents in Drosophila larval neurons: dunce lacks a maintained outward current component downregulated by cAMP. J. Neurosci. 18(4): 1399-1407.

Engel, J. E. and Wu, C. F. (1996). Altered habituation of an identified escape circuit in Drosophila memory mutants. J. Neurosci. 16: 3486-3499

Engels, P., et al. (1995). Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase. J. Neurosci. Res. 41: 169-178

Fagnon, D.D. and Tuchek, J.M. (1995). The biochemistry of learning and memory. Molecular and Cellular Biochemistry 149/150: 279-286

Feany, M. B. (1990). Rescue of the learning defect in dunce, a Drosophila learning mutant, by an allele of rutabaga, a second learning mutant. Proc. Natl. Acad. Sci. 87: 2795-9

Florio, V. A., et al. (1994). Phosphorylation of the 61-kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase at serine 120 reduces its affinity for calmodulin. Biochemistry 33: 8948-8954.

Hanesch, U., Fischbach, K.-F. and Heisenberg, M. (1998). Neuronal architecture of the central complex in Drosophila melanogaster. Cell Tissue Res. 257: 343-366

Hendricks, J. C., et al. (2001). A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat. Neurosci. 4: 1108-1115. 11687816

Iwahashi, Y., et al. (1996). Differential distribution of mRNA encoding cAMP-specific phosphodiesterase isoforms in the rat brain. Brain Res. Mol. Brain Res. 38(1): 14-24.

Jin, S.-L. C., et al. (1999). Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. 96: 11998-12003.

Kandel, E.R. and Hawkins, R.D. (1992). The biological basis of learning and individuality. Sci. Amer. 267(3): 78-86

Kuromi, H. and Kidokoro, Y. (2000). Tetanic stimulation recruits vesicles from reserve pool via a cAMP-mediated process in Drosophila synapses. Neuron 27: 133-143.

Kurusu, M., et al. (2002). Embryonic and larval development of the Drosophila mushroom bodies: concentric layer subdivisions and the role of fasciclin II. Development 129: 409-419. 11807033

Lannutti, B. J. and Schneider, L. E. (2001). Gprk2 Controls cAMP Levels in Drosophila Development. Dev. Biol. 233(1): 174-185. 11319866

Lee, D. and O'Dowd, D. K. (2000). cAMP-dependent plasticity at excitatory cholinergic synapses in Drosophila neurons: Alterations in the memory mutant Dunce. J. of Neurosci. 20(6): 2104-2111.

Levine, J. D., et al. (1994). Altered circadian pacemaker functions and cyclic AMP rhythms in the Drosophila learning mutant dunce. Neuron 13: 967-74

Loughney, K., et al. (1996). Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. J. Biol. Chem. 271: 796-806.

Mohanty, S., et al. (2001). Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium. Genes Dev. 15: 1435-1448. 11390363

Moore, M. S., et al. (1998). Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93: 997-1007.

Nighorn, A., Healy, M. J. and Davis, R. L. (1991). The cyclic AMP phosphodiesterase encoded by the Drosophila dunce gene is concentrated in the mushroom body neuropil. Neuron 6: 455-67

Nighorn, A., Qiu, Y., and Davis, R. L. (1994). Progress in understanding the Drosophila dnc locus. Comp. Biochem. Physiol. Biochem. Mol. Biol. 108: 1-9

Neuser, K., Triphan, T., Mronz, M., Poeck, B. and Strauss, R. (2008). Analysis of a spatial orientation memory in Drosophila. Nature 453(7199): 1244-7. PubMed citation: 18509336

Olsen, A. E. and Bolger, G. B. (2000). Physical mapping and promoter structure of the murine cAMP-specific phosphodiesterase pde4a gene. Mamm. Genome 11(1): 41-5.

Petrovich, T. Z., Merakovsky, J. and Kelly, L. E. (1993). A genetic analysis of the stoned locus and its interaction with dunce, shibire and Suppressor of stoned variants of Drosophila melanogaster. Genetics 133: 955-65

Preat, T. (1998). Decreased odor avoidance after electric shock in Drosophila mutants biases learning and memory tests. J. Neurosci. 18(20): 8534-8.

Putz, G., Bertolucci, F., Raabe, T., Zars, T. and Heisenberg, M. (2004). The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task. J. Neurosci. 24: 9745-9751. PubMed citation: 15525759

Qiu, Y. H., et al. (1991). Characterization of the memory gene dunce of Drosophila melanogaster. J Mol Biol 222: 553-65

Qiu, Y. and Davis, R. L. (1993). Genetic dissection of the learning/memory gene dunce of Drosophila melanogaster. Genes Dev 7: 1447-58

Quinn, W.G., Harris, W.A. and Bencer, S. (1974). Conditioned behavior in Drosophila melanogaster. Proc Natl Acad Sci 71: 708-712

Reed, T. M., et al. (1998). Genomic structure and chromosome location of the murine PDE1B phosphodiesterase gene. Mamm. Genome 9(7): 571-6.

Schuster, C. M., et al. (1996b). Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Neuron 17: 655-667

Shaulsky, G., Fuller, D. and Loomis, W. F. (1998). A cAMP-phosphodiesterase controls PKA-dependent differentiation. Development 125(4): 691-9.

Skoulakis, E. M., Kalderon, D. and Davis, R. L. (1993). Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory. Neuron 11: 197-208

Sonnenburg, W. K., et al. (1995). Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases. J. Biol. Chem. 270: 30989-31000

Spence, S., et al. (1995). Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms. Biochem J 310: 975-982.

Suda, S., et al. (1998). Transcriptional and translational regulation of phosphodiesterase type IV isozymes in rat brain by electroconvulsive seizure and antidepressant drug treatment. J. Neurochem. 71(4): 1554-63.

Swan, A., et al. (2001). Identification of new X-chromosomal genes required for Drosophila oogenesis and novel roles for fs(1)Yb, brainiac and dunce. Genome Res. 11(1): 67-77. 11156616

Tully, T. and Gold, D. (1993). Differential effects of dunce mutations on associative learning and memory in Drosophila. J Neurogenet 9: 55-71

Yan, C., et al. (1994). Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. J. Neurosci. 14: 973-84.

Yao, W.-D., et al. (2000). Spontaneous acetylcholine secretion from developing growth cones of Drosophila central neurons in culture: Effects of cAMP-pathway mutations. J. Neurosci. 20: 2626-2637.

Yun, Y. and Davis, R. L. (1989). Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP. Mol Cell Biol 9: 692-700

Zhao, M.-L., and Wu, C.-F. (1997). Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants. J. Neurosci. 15: 2187-2199.

Zhong, Y. and Wu, C. F. (1991). Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Science 251: 198-201

Zhong, Y., Budnik, V. and Wu, C. F. (1992). Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade. J Neurosci 12: 644-51

Zhong, Y. and Wu, C. F. (1993). Differential modulation of potassium currents by cAMP and its long-term and short-term effects: dunce and rutabaga mutants of Drosophila. J Neurogenet 9: 15-27

date revised: 20 August 2002 

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.