See the embryonic expression pattern of tap at the Berkeley Drosophila Genome Project Patterns of Gene Expression Site.
In the lineage that gives rise to the external sense organs of the peripheral nervous system, the first division of the sensory mother cell gives rise to two second-order precursors, one of which will produce the outer cells that form the external structures of the organ (trichogen and tormogen cells) while the other will form the inner cells of the organ (sheath cells and neurons). In the case of the abdominal chemosensory organs, the lineage produces two types of neurons: two bipolar neurons, which extend their dendrite within the external structures of the organ, and one multidendritic neuron (md) whose dendrites extend under the epidermis and are not connected to the external structure of the organ. Outer and inner cells were distinguished by double labelling with anti-Tap and with 22C10 monoclonal antibody, which labels the membranes of all sensory neurons. The cell containing the Tap protein is localized in the clusters of neurons, and is therefore not one of the outer cells (Gautier, 1997).
Analysis was concentrated on the ventral abdominal poly-innervated organ, the papilla p6, because its two bipolar neurons and their sib md neuron form a small cluster of three cells. The multidendritic neuron is ventral to the other two and is called v'pda. The two bipolar neurons that innervate p6 are dorsal-most and have been collectively called v'es2, since there has been no way to distinguish them from one other. The results suggest that the anterior and posterior v'es2 behave differently, however, and they have been termed v'aes2 (anterior) and v'pes2 (posterior). The anti-Tap antibody appears to label v'aes2, the anterior-most of the two v'es2 neurons. The sheath cell is closely apposed to the neurons, however, and the possibility that Tap is present in the sheath cell cannot be excluded. However, anti-Prospero antibody labels the nuclei of the sheath cells, and anti-Pros and anti-Tap antibodies recognize different cells, confirming that tap is expressed in one of the neurons and not in the sheath cell (Gautier, 1997)
Tap is expressed at a late stage in the development of one type of adult chemosensory organ, the gustatory bristles of the leg, wing and proboscis. tap is also expressed very early in the development of a second type of chemosensory receptor, the olfactory organs of the antenna. The results of behavioral experiments suggest that the ectopic expression of tap affects the response to sugar and salt. The sensitivity to sugar is impared and the sensitivity to salt is increased. It must be noted that the resonse to salt is but an inhibition of the response to sugar, so that the two effects may actually reflect the same cause (Ledent, 1998).
In the pupal wing, immunolabeling reveals expression of Tap from 16 to 22 hours after puparium formation (APF), at the time when the expression of Pox-n is subsiding. Either single cells or pairs of cells are labeled; in the latter case, one cell is usually more intensely labelled than the other cell. Tap is first expressed in a single cell, then in a pair, and finally maintained in only one. The sub-epidermal location of these cells suggests that they are neurons. These results suggests that Tap is first expressed in the neural precursor, then transiently in both daughter cells. It is thought that Tap is expressed in leg chemosensory organs around 10-14 h APF, a period when imaginal discs are refractory to immunolabeling. Tap is expressed in a few cells of the everting leg disc, at positions that suggest that they correspond to the neurons innervating the Keilin organs (Ledent, 1998).
In the case of the proboscis, the precursors of chemosensory organs appear in three waves, at respectively 0, 6, and 24 h APF. At 16 h many clusters of Pox-n-expressing cells are observed. Those clusters near the midline comprise several cells, and correspond to the first wave of precursors. Most other clusters comprise 2-3 cells, and correspond to the precursors of the second wave. This pattern is identical to that observed in the enhancer-trap line A37, which labels all cells of the sensory lineages, suggesting that all organs of the proboscis express Pox-n. The presence of Tap protein is observed from 18 h APF onwards, in single cells or pairs of cells corresponding to the organs of the first wave. Thus in the proboscis as well as in the wing, Tap is expressed in a pattern that largely overlaps the pattern of Pox-n expression, at stages that are consistent with the idea that Tap is expressed at the time chemosensory neurons are just about to, or are beginning to differentiate (Ledent, 1998).
Tap-positive cells are observed in everting antennal discs, at three sites near the base of the third antennal segment. The number of labelled cells at each site increases progressively during the first 6 h APF, from 1-3 to more than 10. This pattern parallels the appearance of precursor cells in this segment as seen in the A101 enhancer-trap line A101, suggesting that Tap is expressed in one subset of olfactory precursors. The position of the labeled cells is consistent with the idea that they may correspond to three large groups of basiconic sensilla found near the junction between the third and the second antennal segment (Ledent, 1998).
Ali, F., et al. (2011). Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development 138(19): 4267-77. PubMed Citation: 21852393
Andersson, E., et al. (2006a). Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2. Development 133(3): 507-16. 16396906
Andersson, E., et al. (2006b). Identification of intrinsic determinants of midbrain dopamine neurons. Cell 124(2): 393-405. 16439212
Andermann, P., Ungos, H. and Raible, D. W. (2002). Neurogenin1 defines zebrafish cranial sensory ganglia precursors. Dev. Bio. 251: 45-58. 12413897
Bae, Y.-K., et al. (2003). A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish. Development 130: 1853-1865. 12642490
Bellefroid, E. J., et al. (1996). X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation. Cell 87(7): 1191-202. 8980226
Berberoglu M. A., Dong Z., Mueller T. and Guo S. (2009). fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene Expr. Patterns 9: 411-422. PubMed Citation: 19524703
Blader, P., et al. (1997). The activity of Neurogenin1 is controlled by local cues in the zebrafish embryo. Development 124(22): 4557-4569. PubMed Citation: 9409673
Blader, P., et al. (2003). Multiple regulatory elements with spatially and temporally distinct activities control neurogenin1 expression in primary neurons of the zebrafish embryo. Mech. Dev. 120: 211-218. 12559493
Blader, P., et al. (2004). Conserved and acquired features of neurogenin1 regulation. Development 131: 5627-5637. 15496438
Boy, S., et al. (2004). XSEB4R, a novel RNA-binding protein involved in retinal cell differentiation downstream of bHLH proneural genes. Development 131: 851-862. 14736748
Bush, A., Cole, Y. and Cole, M. (1996). biparous: a novel bHLH gene expressed in neuronal and glial precursors in Drosophila. Dev. Biol. 180(2): 759-772. PubMed Citation: 8954743
Calella, A. M., et al. (2007). Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription. Neural Develop. 2:4. Medline abstract: 17254333
Cau, E., et al. (1997). Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development 124: 1611-1621. PubMed Citation: 9108377
Cau, E., Casarosa, S. and Guillemot, F. (2002). Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development 129: 1871-1880. 11934853
Cau, E. and Wilson, S. W. (2003). Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis. Development 130: 2455-2466. 12702659
Cho, J. H., Klein, W. H. and Tsai, M. J. (2007). Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina. Mech. Dev. 124(7-8): 543-50. PubMed citation: 17629466
Conte, I., et al. (2010). Proper differentiation of photoreceptors and amacrine cells depends on a regulatory loop between NeuroD and Six6. Development 137(14): 2307-17. PubMed Citation: 20534668
Cornell, R. A., and Eisen, J. S. (2002). Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function. Development 129: 2639-2648. 12015292
Deisseroth, K., et al. (2004). Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron 42: 535-552. 15157417
de la Calle-Mustienes, E., et al. (2002). Xiro homeoproteins coordinate cell cycle exit and primary neuron formation by upregulating neuronal-fate repressors and downregulating the cell-cycle inhibitor XGadd45-gamma. Mech. Dev. 119: 69-80. 12385755
Desgraz, R. and Herrera, P. L. (2009). Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development 136(21): 3567-74. PubMed Citation: 19793886
Dubois, L., et al. (1998). XCoe2, a transcription factor of the Col/Olf-1/EBF family involved in the specification of primary neurons in Xenopus. Curr. Biol. 8(4): 199-209. PubMed Citation: 9501982
Dubreuil, V., et al. (2002). The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis. Development 129: 5241-5253. 12399315
Farah, M. H., et al. (2000). Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127: 693-702.
Fode, C., et al. (1998). The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 20(3): 483-494
Franco, P. G., et al. (1999). Functional association of retinoic acid and hedgehog signaling in Xenopus primary neurogenesis. Development 126: 4257-4265
Friedman, R. A., et al. (2005). Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech. Dev. 122: 625-634. 15817220
Garcia-Dominguez, M., et al. (2003). Ebf gene function is required for coupling neuronal differentiation and cell cycle exit. Development 130: 6013-6025. 14573522
Gaudillière, B., et al. (2004). A CaMKII-NeuroD signaling pathway specifies dendritic morphogenesis. Neuron 41: 229-241. 14741104
Gautier, P., et al. (1997). tap, a Drosophila bHLH gene expressed in chemosensory organs. Gene 191(1):15-21
Geling, A., et al. (2004). Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of Notch to inhibit neurogenesis at the midbrain-hindbrain boundary. Development 131: 1993-2006. 15056616
Gershon, A. A., et al. (2000). The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo. Development 127: 2945-2954
Golson, M. L., et al. (2009). Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech. Dev. 126: 687-699. PubMed Citation: 19501159
Goulding, S. E., White, N. M. and Jarman, A. P. (2000). cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs. Dev. Biol. 221: 120-131.
Gowan, K., et al. (2001). Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons. Neuron 31: 219-232. 11502254
Hand, R., et al. (2005). Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron 48(1): 45-62. 16202708
Hans, S., Scheer, N., Ried, I., v. Weizsäcker, E., Blader, P. and Campos-Ortega, J. A. (2004). her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling. Development 131: 2957-2969. 15169758
Helms, A. W., et al. (2005). Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons. Development 132(12): 2709-19. 15901662
Heng, J. I., et al. (2008). Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature 455(7209): 114-8. PubMed Citation: 18690213
Hirabayashi, Y., et al. (2004). The Wnt/ß-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development 131: 2791-2801. 15142975
Hirabayashi, Y., et al. (2009). Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron 63(5):600-13. PubMed Citation: 19755104
Hutcheson, D. A. and Vetter, M. L. (2001). The bHLH factors Xath5 and XNeuroD can upregulate the expression of XBrn3d, a POU-homeodomain transcription factor. Dev. Bio. 232: 327-338
Ince-Dunn, G., et al. (2006). Regulation of thalamocortical patterning and synaptic maturation by NeuroD2. Neuron 49: 683-695. 16504944
Inoue, T., et al. (2002). Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development 129: 831-842. 11861467
Iulianella, A., et al. (2008). Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis. Development 135: 729-741. PubMed Citation: 18223201
Jenny, M., et al. (2002). Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J. 21: 6338-6347. 12456641
Jeong J. Y., et al. (2007). Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development 134: 127-136. PubMed Citation: 17164418
Johansson, K. A., et al. (2007). Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev. Cell 12(3): 457-65. Medline abstract: 17336910
Kanekar, S., et al. (1997). Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron 19(5): 981-994
Kim, P., et al. (1997). XATH-1, a vertebrate homolog of Drosophila atonal, induces a neuronal differentiation within ectodermal progenitors. Dev. Biol. 187(1): 1-12
Kim, W.-Y., et al. (2001). NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 128: 417-426. 11152640
Kriks, S., Lanuza, G. M., Mizuguchi, R., Nakafuku, M. and Goulding, M. (2005). Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord. Development 132(13): 2991-3002. PubMed citation: 15930101
Kubo, A., et al. (2010). Genomic cis-regulatory networks in the early Ciona intestinalis embryo. Development 137(10): 1613-23. PubMed Citation: 20392745
Lamar, E. and Kintner, C. (2005). The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors. Development 132(16): 3619-30. 16077089
Lawoko-Kerali, G., et al. (2004). GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear. Mech. Dev. 121: 287-299. 15003631
Ledent, V., et al. (1998). Expression and function of tap in the gustatory and olfactory organs of Drosophila. Int. J. Dev. Biol. 42(2): 163-70
Lee, C. S., et al. (2002). Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev. 16: 1488-1497. 12080087
Lee, J. K., et al. (2000). Expression of neuroD/BETA2 in mitotic and postmitotic neuronal cells during the development of nervous system. Dev. Dyn. 217: 361-367. 10767080
Lee, J., et al. (2003). Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord. Dev. Bio. 253: 84-98. 12490199
Lee, S., Lee, B., Lee, J. W. and Lee, S. K. (2009). Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron 62(5): 641-54. PubMed Citation: 19524524
Lee, S. A., et al. (2003). The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Development 130: 2669-2679. 12736211
Lee, S. K. and Pfaff, S. L. (2003). Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron 38(5): 731-45. 12797958
Lee, S.-K., et al. (2004). Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors. Development 131: 3295-3306. 15201216
Lee, S. K., Lee, B., Ruiz, E. C. and Pfaff, S. L. (2005). Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev. 19(2): 282-94. 15655114
Li, S., Mo, Z., Yang, X., Price, S. M., Shen, M. M. and Xiang, M. (2004). Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron 43(6): 795-807. 15363391
Liu, K. J. and Harland, R. M. (2005). Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein. Development 132(7): 1511-23. 15728676
Liu, M., et al. (2000a). Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc. Natl. Acad. Sci. 97: 865-870.
Liu, M., et al. (2000b). Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems. Genes Dev. 14: 2839-2854. 11090132
Ma, Q, Kintner, C. and Anderson, D. J. (1996). Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87: 43-52
Ma, Q., et al. (1998). neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20(3): 469-482. PubMed Citation: 9539122
Mao, C. A., Wang, S. W., Pan, P. and Klein, W. H. (2008). Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. Development 135(20): 3379-88. PubMed Citation: 18787067
Matsuo-Takasaki, M., Lim, J. H. and Sato, S. M. (1999). The POU domain gene, XlPOU 2 is an essential downstream determinant of neural induction. Mech. Dev. 89: 75-85.
Mattar, P., et al. (2004). A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev. Biol. 273: 373-389. 15328020
Matter-Sadzinski, L., et al. (2001). Specification of neurotransmitter receptor identity in developing retina: the chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins. Development 128: 217-231
Matter-Sadzinski, L., et al. (2005). A bHLH transcriptional network regulating the specification of retinal ganglion cells. Development 132(17): 3907-21. 16079155
Mellitzer, G., et al. (2006). IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J. 25(6): 1344-52. 16511571
Miyata, T., et al. (2004). Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells. Development 131: 3133-3145. 15175243
Mizuguchi, R., et al (2001). Combinatorial roles of Olig2 and Neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 31: 757-771. 11567615
Morrow, E. M., et al. (1999). NeuroD regulates multiple functions in the developing neural retina in rodent. Development 126(1): 23-36
Mueller, T. and Wullimann, M. F. (2002). BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain. Mech. Dev. 117: 123-135. 12204253
Mumm, J. S., Williams, P. R., Godinho, L., Koerber, A., Pittman, A. J., Roeser, T., Chien, C. B., Baier, H. and Wong, R. O. (2006). In vivo imaging reveals dendritic targeting of laminated afferents by zebrafish retinal ganglion cells. Neuron 52: 609-621. PubMed Citation: 17114046
Nieto, M., et al. (2001). Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. Neuron 29: 401-413. 11239431
Novitch, B. G., Chen, A., I. and Jessell, T. M. (2001). Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31: 773-789. 11567616
Ochiai, W., et al. (2009). Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells. Mol. Cell. Neurosci. 40: 225-233. PubMed Citation: 19059340
Olson, J. M., et al. (2001). NeuroD2 is necessary for development and survival of central nervous system neurons. Dev. Bio. 234: 174-187. 11356028
Park, H.-C. and Appel, B. (2003). Delta-Notch signaling regulates oligodendrocyte specification. Development 130: 3747-3755. 12835391
Parras, C. M., et al. (2002). Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev. 16: 324-338. 11825874
Perron, M., et al. (1999). X-ngnr-1 and Xath3 promote ectopic expression of sensory neuron markers in the neurula ectoderm and have distinct inducing properties in the retina. Proc. Natl Acad. Sci. 96: 14996-15001.
Philpott, A., Tsai, L. and Kirschner, M. W. (1999). Neuronal differentiation and patterning in Xenopus: The role of cdk5 and a novel activator Xp35.2. Dev. Biol. 207(1): 119-132
Poulin, G., Turgeon, B. and Drouin, J. (1997). NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Mol. Cell. Biol. 17(11): 6673-6682
Quan, X.-J., et al. (2004). Evolution of neural precursor selection: functional divergence of proneural proteins. Development 131: 1679-1689. 15084454
Quiñones, H. I., Savage, T. K., Battiste, J. and Johnson, J. E. (2010). Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages. Dev. Biol. 340(2): 283-92. PubMed Citation: 20171205
Riesenberg, A. N., Le, T. T., Willardsen, M. I., Blackburn, D. C., Vetter, M. L. and Brown, N. L. (2009). Pax6 regulation of Math5 during mouse retinal neurogenesis. Genesis 47: 175-187. PubMed Citation: 19208436
Roztocil, T., et al. (1997). NeuroM, a neural helix-loop-helix transcription factor, defines a new transition stage in neurogenesis. Development. 124(17): 3263-72. PubMed Citation: 9310321
Sansom, S. N., et al. (2009). The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 5(6): e1000511. PubMed Citation: 19521500
Scardigli, R., et al. (2001). Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31: 203-217. 11502253
Scardigli, R., et al. (2003). Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6. Development 130: 3269-3281. 12783797
Schwab, M. H., et al. (1998). Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice. J. Neurosci. 18(4): 1408-1418. PubMed Citation: 9454850
Seibt, J., et al. (2003). Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues. Neuron 39: 439-452. 12895419
Seo, S., Richardson, G. A. and Kroll, K. L. (2005a). The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD. Development 132: 105-115. 15576411
Seo, S., et al. (2005b). Geminin regulates neuronal differentiation by antagonizing Brg1 activity. Genes Dev. 19(14): 1723-34. 16024661
Sharma, A., et al. (1999). The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein binding. Mol. Cell. Biol. 19(1): 704-13. PubMed Citation: 9858593
Shimizu, T., et al. (2010). Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Development 137(11): 1875-85. PubMed Citation: 20431123
Simmons, A. D., et al. (2001). Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers. Dev. Bio. 229: 327-339. 11203697
Skowronska-Krawczyk, D., et al. (2004). Highly specific interactions between bHLH transcription factors and chromatin during retina development. Development 131: 4447-4454. 15342472
Skowronska-Krawczyk, D., et al. (2009). Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis. Development 136(22): 3767-77. PubMed Citation: 19855019
Sobieszczuk, D. F., Poliakov, A., Xu, Q. and Wilkinson, D. G. (2010). A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation. Genes Dev. 24(2): 206-18. PubMed Citation: 20080956
Sugimori, M., et al. (2007). Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord. Development 134(8): 1617-29. Medline abstract: 17344230
Sun, Y., et al. (2001). Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104: 365-376. 11239394
Talikka, M., Perez, S. E. and Zimmerman, K. (2002). Distinct patterns of downstream target activation are specified by the helix-loop-helix domain of proneural basic helix-loop-helix transcription factors. Dev. Bio. 247: 137-148. 12074558
Tessmar, K., Loosli, F. and Wittbrodt, J. (2002). A screen for co-factors of Six3. Mech. Dev. 117: 103-113. 12204251
Ungos, J. M., Karlstrom, R. O. and Raible, D. W. (2003). Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons. Development 130: 5351-5362. 13129844
Willardsen, M. I., Suli, A., Pan, Y., Marsh-Armstrong, N., Chien, C. B., El-Hodiri, H., Brown, N. L., Moore, K. B. and Vetter, M. L. (2009). Temporal regulation of Ath5 gene expression during eye development. Dev. Biol. 326: 471-481. PubMed Citation: 19059393
Yechoor, V., et al. (2009). Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev. Cell 16(3): 358-73. PubMed Citation: 19289082
date revised: 28 December 2011
Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.
The Interactive Fly resides on the
Society for Developmental Biology's Web server.