ß amyloid protein precursor-like

REFERENCES

Allinquant. B., et al. (1994). Amyloid precursor protein in cortical neurons: coexistence of two pools differentially distributed in axons and dendrites and association with cytoskeleton. J. Neurosci. 1: 6842-54.

Allinquant, B., et al. (1995). Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro. J. Cell Biol. 128(5): 919-27.

Ando, K., et al. (1999). Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J. Neurosci. 19(11): 4421-7.

Apert, C., et al. (1998). Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus. J. Neuroendocrinol. 10(2): 101-9.

Baek, S.-H., et al. (2002). Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and ß-amyloid precursor protein. Cell 110: 55-67. 12150997

Bao, J., Cao, C., Zhang, X., Jiang, F., Nicosia, S. V. and Bai, W. (2006). Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65. Mol. Cell. Biol. 27(4): 1321-33. Medline abstract: 17130235

Billings, L. M., et al. (2005). Intraneuronal Aß causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45: 675-688. 15748844

Borg, J. P., et al. (1998). The X11 protein slows cellular amyloid precursor protein processing and reduces Aß40 and Aþß2 secretion. J. Biol. Chem. 273: 14761-14766. 9614075

Bothwell, M. and Giniger, E. (2000). Alzheimer's disease: neurodevelopment converges with neurodegeneration. Cell 102: 271-273. 10975517

Bowman, A. B., Kamal, A., Philip, A. V., Ritchings, B. W., Laymon, R. A., McGrail, M., Gindhart, J. G. and Goldstein, L. S. B. (2000). Kinesin dependent axonal transport is mediated by the Sunday driver protein. Cell 103: 583-594.

Budnik, V., Zhong, Y. and Wu, C.-F. (1990) Morphological plasticity of motor axon terminals in Drosophila mutants with altered excitability. J. Neurosci. 10: 3754-3768.

Busciglio, J., et al. (2002). Altered metabolism of the amyloid ß precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33: 677-688. 11879646

Buxbaum, J. D., et al. (1998). Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J. Neurosci. 18(23): 9629-37.

Caillé, I., et al. (2004). Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 131: 2173-2181. 15073156

Cao, X. and Sudhof, T. C. (2001). A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293(5527): 115-20. 11441186

Cao, X. and Sudhof, T. C. (2004). Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J. Biol. Chem. 279(23): 24601-11. Medline abstract: 15044485

Caswell, M. D., et al. (1999). The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons. Eur. J. Biochem. 266(2): 509-516

Chapman, P. F., et al. (1999). Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat. Neurosci. 2(3): 271-6.

Daigle, I. and Li, C. (1993). apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor. Proc. Natl. Acad. Sci. 90(24): 12045-9.

Deane, R., et al. (2004). LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 43(3): 333-44. 15294142

Eckman, E. A., Watson, M., Marlow, L., Sambamurti, K., and Eckman, C. B. (2003). Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J. Biol. Chem. 278: 2081-2084. 12464614

Farris, W., et al. (2003). Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. 100: 4162-4167. 12634421

Fossgreen, A., et al. (1998). Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype. Proc. Natl. Acad. Sci. 95(23): 13703-8.

Frears, E. R., et al. (1999). The role of cholesterol in the biosynthesis of ß-amyloid. Neuroreport 10: 1699-1705. 10501560

Furukawa, K., et al. (1996). Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature 379(6560): 74-8.

Furukawa, K. and Mattson, M. P. (1998). Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP. Neuroscience 83(2): 429-38.

Gao, Y. and Pimplikar, S. W. (2001). The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc. Natl. Acad. Sci. 98: 14979-14984. 11742091

Giambarella, U., et al. (1997). G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J. 16(16): 4897-907.

Giniger, E. (1998) A role for Abl in Notch signaling. Neuron 20: 667-681. 9581760

Greenberg, S. M., et al. (1994). Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc. Natl. Acad. Sci. 91(15): 7104-8.

Gunawardena, S. and Goldstein, L. S. B. (2001). Disruption of axonal transport and neuronal viability by Amyloid precursor protein mutations in Drosophila. Neuron 32: 389-401. 11709151

Haass, C., et al. (1995). Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. J. Cell Biol. 128(4): 537-47.

Hook, V. Y., et al. (1999). The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. J. Biol. Chem. 274(5): 3165-72.

Howell, B. W., et al. (1999). The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids. Mol. Cell. Biol. 19(7): 5179-88.

Ishida A., et al. (1997). Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices. NeuroReport 8: 2133-213.

Iwata, N., et al. (2001). Metabolic regulation of brain Abeta by neprilysin. Science 292: 1550-1552. 11375493

Kamal, A., et al. (2000). Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of Kinesin-I. Neuron 28: 449-459.

Kamenetz, F., et al. (2003). APP processing and synaptic function. Neuron 37: 925-937. 12670422

Kim, T. W., et al. (1995). Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Res. Mol. Brain Res. 32(1): 36-44.

Kimberly, W. T., et al. (2000). The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J. Biol. Chem. 275(5): 3173-8.

Koo, E. H., et al. (1996). Trafficking of cell-surface amyloid -protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J. Cell Sci. 109: 991-998.

Koudinova, N. V., Berezov, T. T. and Koudinov, A. R. (1996). Multiple inhibitory effects of Alzheimerís peptide Aß1-40 on lipid biosynthesis in cultured human HepG2 cells. FEBS Lett. 395: 204-206. 8898096

Kuner. P., Schubenel, R. and Hertel, C. (1998). Beta-amyloid binds to p57NTR and activates NFkappaB in human neuroblastoma cells. J. Neurosci. Res. 54(6): 798-804.

Leissring, M. A., et al. (2003). Enhanced proteolysis of ß-Amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40: 1087-1093. 14687544

Li, H. L., et al. (1997). Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease. J. Neurobiol. 32(5): 469-80.

Lin, H., Lin, T. Y. and Juang, J. L. (2007). Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration. Cell Death Differ. 14(3): 607-15. Medline abstract: 16932754

Liebl, E. C., et al. (2003). Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding. Development 130: 3217-3226. 12783792

Liu, Y., Peterson, D. A. and Schubert, D. (1998). Amyloid ß peptide alters intracellular vesicle trafficking and cholesterol homeostasis. Proc. Natl. Acad. Sci. 95: 13266-13271. 9789077

Luo, J. J., et al. (1999). Death of PC12 cells and hippocampal neurons induced by adenoviral-mediated FAD human amyloid precursor protein gene expression. J. Neurosci. Res. 55(5): 629-42.

Luo, L. Q., Martin-Morris, L. E., White, K. (1990). Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor. J. Neurosci. 10(12): 3849-61.

Luo, L. Q., Tully, T. and White, K. (1992). Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9(4): 595-605.

Lyckman, A. W., et al. (1998). Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system. J. Biol. Chem. 273(18): 11100-6.

Marquez-Sterling, N. R., et al. (1997). Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. J. Neurosci. 17(1): 140-51.

Martin-Morris, L. E. and White, K. (1990). The Drosophila transcript encoded by the beta-amyloid protein precursor-like gene is restricted to the nervous system. Development 110(1): 185-95.

Matsuda, S., et al. (2001). c-Jun N-terminal kinase (JNK)-interacting protein-1b/Islet-Brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J. Neurosci. 21(17): 6597-6607. 11517249

Mattson, M. P., Guo, Z. H. and Geiger, J. D. (1999). Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism. J. Neurochem. 73(2): 532-7.

McGowan, E., et al. (2005). Aß42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47: 191-199. 16039562

Merdes, G., Soba, P., Loewer, A., Bilic, M. V., Beyreuther, K. and Paro, R. (2004). Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J. 23(20): 4082-95. 15385958

Miller, B. C., et al. (2003). Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc. Natl. Acad. Sci. 100: 6221-6226. 12732730

Morimoto T., et al. (1998). Involvement of amyloid precursor protein in functional synapse formation in cultured hippocampal neurons. J. Neurosci. Res. 51(2): 185-95.

Müller, U., et al. (1994). Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell 79: 755-765.

Muresan, Z. and Muresan, V. (2005). Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J. Cell Biol. 171(4): 615-25. Medline abstract: 16301330

Nishimoto, I., et al. (1993). Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G. Nature 362(6415): 75-9.

Nitsch, R. M., et al. (1992). Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258(5080): 304-7.

Nitsch, R. M., et al. (1993). Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proc. Natl. Acad. Sci. 90(11): 5191-3.

Nitsch. R. M., Kim, C. and Growdon, J. H. (1998). Vasopressin and bradykinin regulate secretory processing of the amyloid protein precursor of Alzheimer's disease. Neurochem. Res. 23(5): 807-14.

Okado, H. and Okamoto, H. (1992). A Xenopus homologue of the human beta-amyloid precursor protein: developmental regulation of its gene expression. Biochem. Biophys. Res. Commun. 189(3): 1561-8.

Okamoto, T., et al. (1995). Ligand-dependent G protein coupling function of amyloid transmembrane precursor. J. Biol. Chem. 270(9): 4205-8.

Okamoto, T., et al. (1996). Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease. EMBO J. 15(15): 3769-77.

Olry, A., et al. (2005). Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein. J. Biol. Chem. 280(31): 28564-71. 15958385

Olson, E. C., Kim, S. and Walsh, C. A. (2006). Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. J. Neurosci. 26(6): 1767-75. 16467525

Pardossi-Piquard, R., et al. (2005). Presenilin-dependent transcriptional control of the Aß-degrading enzyme Neprilysin by intracellular domains of ßAPP and APLP. Neuron 46: 541-554. 15944124

Perez, R. G., et al. (1999). Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J. Biol. Chem. 274(27): 18851-6.

Phiel, C. J., et al. (2003). GSK-3alpha regulates production of Alzheimer's disease amyloid-ß peptides. Nature 423(6938): 435-9. 12761548

Pietrzik, C. U., et al. (1998). From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc. Natl. Acad. Sci. 95(4): 1770-5.

Pramatarova, A., Ochalski, P. G., Lee, C. H. and Howell, B. W. (2006). Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model. Mol. Cell. Biol. 26(4): 1510-7. 16449660

Puglielli, L., et al. (2001). Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid ß-peptide. Nat. Cell Biol. 3: 905-912. 11584272

Qiu, W. Q., et al. (1995). Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J. Neurosci. 15(3 Pt 2): 2157-67.

Querfurth, H. W., et al. (1999). Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter. Gene 232(1): 125-41.

Roch, J. M., et al. (1994). Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc. Natl. Acad. Sci. 91(16): 7450-4.

Roncarati, R., Sestan, N., Scheinfeld, M. H., Berechid, B. E., Lopez, P. A, Meucci, O., McGlade, J. C., Rakic, P. and D'Adamio, L. (2002). The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc. Natl. Acad. Sci. 99: 7102-7107. 12011466

Rosen, D. R., et al. (1989). A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor. Proc. Natl. Acad. Sci. 86(7): 2478-82. 89184650

Rossner, S., et al. (1998). p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells. J. Neurochem. 71(2): 757-66.

Sabo, S. L., et al. (1999). Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. J. Biol. Chem. 274(12): 7952-7.

Seabrook, G. R., et al. (1999). Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology 38(3): 349-59.

Simons, M., et al. (1998). Cholesterol depletion inhibits the generation of ß-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. 95: 6460-6464. 9600988

Sinha, S. and Lieberburg, I. (1999). Cellular mechanisms of beta-amyloid production and secretion. Proc. Natl. Acad. Sci. 96: 11049-11053.

Skovronsky, D. M., et al. (2000). Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J. Biol. Chem. 275(4): 2568-75.

Slack, B. E., et al. (1993). Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha. J. Biol. Chem. 268(28): 21097-101.

Soriano, S., et al. (1999). Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments. J. Biol. Chem. 274(45): 32295-300.

Struhl, G. and Adachi, A. (2000). Requirements for Presenilin-dependent cleavage of Notch and other transmembrane proteins. Molec. Cell 6: 625-636

Takahashi, M., et al. (2000). Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron 28: 461-473.

Takasugi, N., et al. (2002). The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J. Biol. Chem. 277: 50198-50205. 12388554

Taru, H., Iijima, K., Hase, M., Kirino, Y., Yagi Y. and Suzuki.T. (2002). Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J. Biol. Chem. 277: 20070-20078. 11912189

Torroja, L., Luo, L. and White, K. (1996). APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons. J. Neurosci. 16: 4638-4650.

Torroja, L., et al. (1999). Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr. Biol. 9(9): 489-92.

Trommsdorff, M., et al. (1998). Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem. 273(50): 33556-60.

Tschäpe1, J. A., et al. (2002). The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing. EMBO J. 21: 6367-6376. 9600988

Van Doren, M., Broihier, H. T., Moore, L. A. and Lehmann, R. (1998). HMG-CoA reductase guides migrating primordial germ cells. Nature 396: 466-469. 9853754

Vassar, R., et al. (1999). Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286(5440): 735-41.

von Rotz, R. C., et al. (2004). The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J. Cell Sci. 117(Pt 19): 4435-48. Medline abstract: 15331662

Wallace, W. C., Akar, C. A. and Lyons, W. E. (1997a). Amyloid precursor protein potentiates the neurotrophic activity of NGF. Brain Res. Mol. Brain Res. 52(2): 201-12.

Wallace, W. C., et al. (1997b). Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity. Brain Res. Mol. Brain Res. 52(2): 213-27.

Walsh, D. M., et al. (2002). Naturally secreted oligomers of amyloid ß protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416: 535-9. 11932745

Wong, T. P., et al. (1999). Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes. J. Neurosci. 19(7): 2706-16.

Xia, W., et al. (1997). Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J. Biol. Chem. 272(12): 7977-82.

Yamatsuji, T., et al. (1996). G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Science 272(5266): 1349-52.

Yan, R., et al. (1999). Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402(6761): 533-7.

Yu, H., et al. (2001). APP processing and synaptic plasticity in Presenilin-1 conditional knockout mice. Neuron 31: 713-726. 11567612

Zambrano, N., et al. (2001). The ß-Amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. J. Biol. Chem. 276: 19787-19792. 11279131

Zambrano, N., et al. (2001). The ß-Amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. J. Biol. Chem. 276: 19787-19792. 11279131

Zheng, H., et al. (1995). beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81: 525-531.

Zhou, S., et al. (2005). CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta- peptide production. Proc. Natl. Acad. Sci. 102: 7499-7504. Medline abstract: 15890777

date revised: 17 January 2008

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.