Djun

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Agarwal, S. K., et al. (1999). Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96(1): 143-52

Bakiri, L., et al. (2000). Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression. EMBO J. 19: 2056-2068

Barila, D., et al. (2000). A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK. EMBO J. 19: 273-281.

Behrens, A., Sibilia, M. and Wagner, E. F. (1999). Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 21(3): 326-9

Behrens, A., et al. (2002). Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J. 21: 1782-1790. 11927562

Behrens, A., et al. (2003). Impaired intervertebral disc formation in the absence of Jun. Development 130(1): 103-9. 12441295

Bohmann, D., et al. (1994). Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78: 973-986

Borchiellini, C., Coulon, J. and Le Parco, Y. (1996). The function of type IV collagen during Drosophila embryogenesis. Wilhelm Roux's Arch. Dev. Biol. 205: 468-475

Bossis, G., et al. (2005). Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol. Cell. Biol. 25(16): 6964-79. 16055710

Boutros, M., et al. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94(1): 109-118

Busygina, V., et al. (2004). Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Hum. Mol. Genet. 13: 2399-2408. Medline abstract: 15333582

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Caelles, C., et al. (1997). Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev. 11(24): 3351-3364

Cerrato, A., et al. (2006). Genetic interactions between Drosophila melanogaster menin and Jun/Fos. Dev. Biol. 298(1): 59-70. Medline abstract: 16930585

Ciapponi, L. and Bohmann, D. (2002). An essential function of AP-1 heterodimers in Drosophila development. Mech. Dev. 115: 35-40. 12049765

Claret, F.-X., et al. (1996). A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature 383: 453-457

Clarke, N., et al. (1998). Epidermal growth factor induction of the c-jun promoter by a Rac pathway. Mol. Cell. Biol. 18(2): 1065-1073

Clayton, A. L., et al. (2000). Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J. 19: 3714-3726.

Cook, S. J., Aziz, N. and McMahon, M. (1999). The repertoire of Fos and Jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Mol. Cell. Biol. 19(1): 330-41

Cruzalegui, F. H., Hardingham, G. E. and Bading, H. (1999). c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation. EMBO J. 18(5): 1335-44

de Groot, R. P., et al. (1993). Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy. Oncogene 8: 841-7

Efer, R., et al. (2003). Liver tumor development: c-jun antagonizes the proapoptotic activity of p53. Cell 112: 181-192. 12553907

Fang, X., et al. (1997). Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity. J. Biol. Chem. 272 (21): 13683-13689

Faris, M., et al. (1998). Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Mol. Cell. Biol. 18(9): 5414-24

Gaiddon, C., Loeffler, J. P., and Larmet, Y. (1996). Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons. J. Neurochem. 66: 2279-2286

Geles, K. G., Freiman, R. N., Liu, W. L., Zheng, S., Voronina. E. and Tjian, R. (2006). Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks. Proc. Natl. Acad. Sci. 103(8): 2594-9. 16473943

Gerald, D., et al. (2004). JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 118(6): 781-94. 15369676

Gritzan, U., Weiss, C., Brennecke, J. and Bohmann, D. (2002). Transrepression of AP-1 by nuclear receptors in Drosophila. Mech. Dev. 115: 91-100. 12049770

Grotewold, L. and Rüther, U. (2002). The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death. EMBO J. 21: 966-975. 11867524

Groupp, E. R. and Donovan-Peluso, M. (1997). Lipopolysaccharide induction of THP-1 cells activates binding of c-Jun, Ets, and Egr-1 to the tissue factor promoter. J. Biol. Chem. 271(21): 12423-12430

Han, T. H. and Prywes, R. (1995). Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol. Cell. Biol. 15 (6): 2907-2915

Han, Z. S., et al. (1998). A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol. Cell. Biol. 18(6): 3527-39.

Herzog, K. H., Chen, S. C. and Morgan, J. I. (1999). c-jun is dispensable for developmental cell death and axogenesis in the retina. J. Neurosci. 19(11): 4349-59

Hou, X. S., Goldstein, E. S. and Perrimon, N. (1997). Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes Dev. 11:1728-1737

Ivanov, V. N., et al. (2001). Cooperation between STAT3 and c-Jun suppresses Fas transcription. Molec. Cell 7: 517-528

Isaksson, A., et al. (1997). The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development. Mech. Dev. 68(1-2): 59-67

Kardassis, D., et al. (1999). c-Jun transactivates the promoter of the human p21WAF1/Cip1 gene by acting as a superactivator of the ubiquitous transcription factor Sp1. J. Biol. Chem. 274: 29572-29581

Karin, M. (1995). The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270: 16483

Kassel, O., et al. (2004). A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters. Genes Dev. 18: 2518-2528. 15489293

Kawasaki, H., et al. (1998). p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. Genes Dev. 12: 233-245

Kerppola, T. K. and Curran, T. (1997). The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions. EMBO J. 16: 2907-16

Kim, T., Yoon, Y., Cho, H., Lee, W-B., Kim, J., Song, Y-H., Kim, S.N., Yoon, J.H., Kim-Ha, J. and Kim, Y-J. (2005). Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP-1 and the NF-kappaB signaling modules. Nat. Immunol. 6: 211-218. 15640802

Knochel, S., Schuler-Metz, A. and Knochel, W. (2000). c-Jun (AP-1) activates BMP-4 transcription in Xenopus embryos. Mech. Dev. 98: 29-36.

Kockel, L., et al. (1997). Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev. 11:1748-1758

Kralova, J., et al. (1996). Synergistic stimulation of avian IkappaBalpha transcription by rel and fos/jun factors. Oncogene 12: 2595-2604

Kramer, B., Wiegmann, K. and Kronke, M. (1995). Regulation of the human TNF promoter by the transcription factor Ets. J Biol Chem 270: 6577-6583

Kallunki, T., et al. (1996). cJun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87: 929-939

Lamb, J. A., et al. (2003). JunD mediates survival signaling by the JNK signal transduction pathway. Molec. Cell 11: 1479-1489. 12820962

Leppa, S., et al. (1998). Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO J. 17: 4404-4413

Li, G., et al. (2003). c-Jun is essential for organization of the epidermal leading edge. Dev. Cell 4: 865-877. 12791271

Liberati, N. T., et al. (1999). Smads bind directly to the jun family of AP-1 transcription factors. Proc. Natl. Acad. Sci. 96(9): 4844-9

Lively, T. N., Nguyen, T. N., Galasinski, S. K. and Goodrich, J. A. (2004). The basic leucine zipper domain of c-Jun functions in transcriptional activation through interaction with the N terminus of human TATA-binding protein-associated factor-1 (human TAF(II)250). J. Biol. Chem. 279(25): 26257-65. Medline abstract: 15087451

Macian, F., García-Rodriguez, C. and Rao, A.2 (2000). Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J. 19: 4783-4795.

Malliri, A., et al. (1998). The transcription factor AP-1 Is required for EGF-induced activation of Rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. J. Cell Biol. 143(4): 1087-1099

Marinissen, M. J., et al. (1999). A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5. Mol. Cell Biol. 19(6): 4289-301

Martin-Blanco, E., et al. (1998). puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila Genes Dev. 12: 557-570

May, G. H. W., et al. (1998). An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo. Curr. Biol. 8(2): 117-120

McDonough, P. M., et al. (1997). Collaborative roles for c-Jun N-terminal kinase, c-Jun, Serum response factor, and Sp1 in calcium-regulated myocardial gene expression. J. Biol. Chem. 272(38): 24046-24053.

Mettouchi, A., et al. (1997). The c-Jun-indued transformation process involves complex regulation of Tenascin-C expression. Mol. Cell. Biol. 17: 3202-3209

Malliri, A., et al. (1998). The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. J. Cell Biol. 143(4): 1087-99

Mechta-Grigoriou, F., et al. (2003). c-jun regulation and function in the developing hindbrain. Dev. Biol. 258: 419-431. 12798298

Mihaly, J., et al. (2001). The role of the Drosophila TAK homologue dTAK during development. Mech. Dev. 102(1-2): 67-79. 11287182

Miotto, B., Sagnier, T., Berenger, H., Bohmann, D., Pradel, J. and Graba, Y. (2005). Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Genes Dev. 20(1): 101-12. 16391236

Monnier, D. and Loeffler, J. P. (1998). Pituitary adenylate cyclase-activating polypeptide stimulates proenkephalin gene transcription through AP1- and CREB-dependent mechanisms. DNA Cell Biol. 17(2): 151-159

Naumann M., Bech-Otschir D., Huang X., Ferrell K. and Dubiel W. (1999). COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J. Biol. Chem. 274: 35297-35300. 10585392

Nead, N. A., et al. (1998). Rb binds c-Jun and activates transcription. EMBO J. 17: 2342-2352

Ng, K. W., et al. (1997). The binding of a Fos/Jun heterodimer can completely disrupt the structure of a nucleosome. EMBO J. 16: 2072-85

Ogryzko, V. V., et al. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953-959

Oren, A., et al. (1999). The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner. Mol. Cell. Biol. 19(3): 1742-50

Ouwens, D. M., et al. (2002). Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. EMBO J. 21: 3782-3793. 12110590

Papaconstantinou, M., et al. (2005). Menin is a regulator of the stress response in Drosophila melanogaster, Mol. Cell. Biol. 25: 9960-9972. Medline abstract: 16260610

Passegue, E., Wagner, E. F. and Weissman, I. L. (2004). JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 119(3): 431-43. 15507213

Perkins, K. K., Dailey, G. M. and Tjian, R. (1988). Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1.EMBO J 7: 4265-73

Perkins, K. K., et al. (1990). The Drosophila Fos-related AP-1 protein is a developmentally regulated transcription factor. Genes Dev 4: 822-34

Peverali, F. A., et al. (1996). Phosphorylation of Drosophila Jun by the MAP kinase Rolled regulates photoreceptor differentiation. EMBO J. 15: 3943-50

Rajaram, N. and Kerppola, T. K. (1997). DNA bending by Fos-Jun and the orientation of heterodimer binding depend on the sequence of the AP-1 site. EMBO J 16 (10): 2917-2925

Ricci, R., et al. (2005). Distinct functions of junD in cardiac hypertrophy and heart failure. Genes Dev. 19: 208-213. 15655111

Riesgo-Escovar, J. R. and Hafen, E. (1997a). Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev. 11:1717-1727

Riesgo-Escovar, J. R. and Hafen, E. (1997b). Common and distinct roles of DFos and DJun during Drosophila development. Science 278(5338): 669-672

Scholz, H., et al. (1997). Control of midline glia development in the embryonic Drosophila. Mech. Dev. 62: 79-91

Schreiber, M., et al. (1999). Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13(5): 607-619

See, R. H. and Shi, Y. (1998). Adenovirus E1B 19,000-molecular-weight protein activates c-Jun N-terminal kinase and c-Jun-mediated transcription. Mol. Cell. Biol. 18(7): 4012-4022

Shaulian, E., et al. (2000). The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 103: 897-907.

Shimizu, M., et al. (1998). Activation of the rat cyclin a promoter by ATF2 and Jun family members and its suppression by ATF4. Exp. Cell Res. 239(1): 93-103

Sitlani, A. and Crothers, D. M. (1998). DNA-binding domains of Fos and Jun do not induce DNA curvature: An investigation with solution and gel methods. Proc. Natl. Acad. Sci. 95(4): 1404-1409

Stronach, B. and Perrimon, N. (2002). Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev. 16: 377-387. 11825878

Su, Y.-C., Treisman, J. E. and Skolnik, E. Y. (1998). The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway. Genes Dev. 12: 2371-2380

Suzanne, M., Perrimon, N. and Noselli, S. (2001). The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev. Bio. 237: 282-294. 11543614

Szabowski, A., et al. (2000). c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell 103: 745-755.

Szuts, D. and Bienz, M. (2000). LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator. Proc. Natl. Acad. Sci. 97: 5351-5356.

Thépot, D., et al. (2000). Targeted disruption of the murine junD gene results in multiple defects in male reproductive function. Development 127: 143-153.

Treier, M., Bohmann, D. and Mlodzik, M. (1995). JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell 83: 753-760

Vallone, D., et al. (1997). Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product. EMBO J. 16(17): 5310-5321

Wang, G. L. and Goldstein, E. S. (1994). Transcription of DJun from D. melanogaster is positively regulated by DTF-1, AP-1, and CREB binding sites. Exp. Cell Res. 214: 389-399

Watson, A., et al. (1998). Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J. Neurosci. 18(2): 751-762

Weber, U., Paricio, N. and Mlodzik, M. (2000). Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 127: 3619-3629

Weitzman, J. B., et al. (2000). JunD protects cells from p53-dependent senescence and apoptosis. Mol. Cell 6: 1109-1119.

Westermarck, J., et al. (2002). The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription. EMBO J. 21: 451-460. 11823437

Whitfield, J., et al. (2001). Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial Cytochrome c release. Neuron 29: 629-643. 11301023

Wisdom, R., Johnson, R. S. and Moore, C. (1999). c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18(1): 188-97

Wollnik, F., et al. (1995). Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced phase shifts of the mammalian circadian clock. Eur. J. Neurosci. 7(3): 388-93

Wong, C., et al. (1999). Smad3-smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. Mol. Cell. Biol. 19(3): 1821-30

Yao, J., et al. (1997). Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors. J. Biol. Chem. 272(28): 17795-17801

Zagariya, A., et al. (1998). Tumor necrosis factor alpha gene regulation: enhancement of C/EBPbeta-induced activation by c-Jun. Mol. Cell. Biol. 8(5): 2815-2824

Zanger, K. Radovick, S. and Wondisford, F. E. (2001). CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box. Molec. Cell 7: 551-558

Zenz, R., et al. (2003). c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev. Cell 4: 879-889. 12791272

Zhang, K., et al. (1990). Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc Natl Acad Sci 87: 6281-5

Zhang, Y., Feng, X. H. and Derynck, R. (1998). Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394: 909-913

date revised: 15 April 2007

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