apterous
Adams, K. A., et al. (2000). The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer. Development 127: 1857-1867. 10751174
Agulnick, A. D., et al. (1996). Interactions of the LIM-domain-binding factor Lbd1 with LIM homeodomain proteins. Nature 384: 270-272
Allan, D., St. Pierre, S. E., Miguel-Aliaga, I. and Thor, S. (2003). Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell 113: 73-86. 12679036
Allan, D. W., Park, D., St. Pierre, S. E., Taghert, P. H. and Thor, S. (2005). Regulators acting in combinatorial codes also act independently in single differentiating neurons. Neuron 45: 689-700. 15748845
Altun-Gultekin, Z., et al. (2001). A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. Development 128: 1951-1969
Appel, B., et al. (1995). Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development 121: 4117-4125
Averof, M. and Cohen, S. M. (1997). Evolutionary origin of insect wings from ancestral gills. Nature 385: 627-630
Bach, I., et al. (1997). A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev. 11(11): 1370-1380
Bach, I., et al. (1999). RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 22(4): 394-9
Bachmann, A. and Knust, E. (1998b). Positive and negative control of Serrate expression during early development of the Drosophila wing. Mech. Dev. 76(1-2): 67-78
Bachy, I., Vernier, P. and Rétaux, S. (2001). The LIM-homeodomain gene family in the developing Xenopus brain: Conservation and divergences with the mouse related to the evolution of the forebrain. J. Neurosci. 21(19): 7620-7629. 11567052
Barnes, J. D., et al. (1994). Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev Biol 161: 168-78
Beck, C. W. and Slack, J. M. W. (1998). Analysis of the developing Xenopus tail bud reveals separate phases of gene expression during determination and growth. Mech. Dev. 72(1-2): 41-52
Bendall, A. J., et al. (1998). Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation 63(3): 151-7
Benveniste, R. J., et al. (1998). Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development 125: 4757-4765
Bernard, F., et al. (2003). Control of apterous by vestigial drives indirect flight muscle development in Drosophila. Dev. Biol. 260: 391-403. 12921740
Bertuzzi, S. (1999). Characterization of lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex. Mech. Dev. 81(1-2): 193-8
Blair, S.S., Brower, D.L., Thomas, J.B. and Zavortink, M. (1994). The role of apterous in the control of dorso/ventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. Development 120: 1805-1815
Blair, S.S. (1995). Compartments and appendage development in Drosophila. Bioessays 17: 299-309
Bourgouin, C., Lundgren, S.E. and Thomas, J.B. (1992). Apterous is a Drosophila LIM-domain gene required for embryonic muscle development. Neuron 9: 549-561
Breen, J. J., et al. (1998). Interactions between LIM Domains and the LIM Domain-binding Protein Ldb1. J. Biol. Chem. 273(8): 4712-4717
Bulchand, et al. (2001). LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech. Dev. 100: 165-175. 11165475
Campbell, G. (2005). Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15. Dev. Biol. 278(2): 607-18. 15680373
Capovilla, M., Kambris, Z. Botas, J. (2001). Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm. Development 128: 1221-1230. 11262224
Cassata, G., et al. (2000). The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans. Neuron 25: 587-597.
Chen, H., et al. (1998). Multiple calvarial defects in lmx1b mutant mice. Dev. Genet. 22(4): 314-320
Choi, G. B., et al. (2005). Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Neuron 46: 647-660. 15944132
Claridge-Chang, A., et al. (2001). Circadian regulation of gene expression systems in the Drosophila head. Neuron 32: 657-671. 11719206
Cygan, J. A., Johnson, R. L. and McMahon, A. P. (1997). Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development 124(24): 5021-5032
Dawid, I. B., Toyama, R. and Taira, M. (1995). LIM domain proteins. C R Acad Sci III 318: 295-306
Delanoue, R., et al. (2002). Interaction between apterous and early expression of vestigial in formation of the dorso-ventral compartments in the Drosophila wing disc. Genes Cells 7(12): 1255-66. 12485165
Ensini, M., et al. (1998). The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm. Development 125: 969-982
Ericson, J., et al. (1998). Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 125(6): 1005-1015
Fernández-Fúnez, P., et al. (1998). The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing. EMBO J. 17: 6846-6853
Fujii, T., et al. (1994). Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system. Dev. Dyn. 199: 73-83
Garcia-Bellido, A. (1975). Genetic control of wing disc development in Drosophila. In: Porter, R. and Rivers, J. (eds) Cell Patterning. CIBA Symposium vol 29: 161-182. Little Brown, Boston.
Ghazi, A., Anant, S. and VijayRaghavan, K. (2000). Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cues. Development 127: 5309-5318.
Girardin, S. E., et al. (1998). The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells. FEBS Lett. 431(3): 333-8
Glasgow, E., Karavanov, A. A. and Dawid, I. B. (1997). Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in mutant zebrafish with axial signaling defects. Dev. Biol. 192(2): 405-419
Glenn, D. J. and Maurer, R. A. (1999). MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. 274(51): 36159-67.
Gohl, D., Müller, M., Pirrotta, V., Affolter, M. and Schedl, P. (2008). Enhancer blocking and transvection at the Drosophila apterous locus. Genetics 178(1): 127-43. PubMed Citation: 18202363
Grigoriou, M., et al. (1998). Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development 125: 2063-2074
Herrero, P., et al. (2007). Squeeze involvement in the specification of Drosophila leucokinergic neurons: Different regulatory mechanisms endow the same neuropeptide selection. Mech. Dev. 124(6): 427-40. Medline abstract: 17442544
Herzig, M. C., et al. (2001). Expression and function of the LIM homeodomain protein Apterous during embryonic brain development of Drosophila. Dev. Genes Evol. 211: 545-554
Hiratani, I., et al. (2001). Functional domains of the LIM homeodomain protein Xlim-1 involved in negative regulation, transactivation, and axis formation in Xenopus embryos. Dev. Biol. 229: 456-467. 11203702
Hiratani, I., et al. (2003), Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions. Development 130: 4161-4175. 12874135
Hobert, O., et al. (1997). Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19(2): 345-57
Hobert, O., et al. (1998). Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J. Neurosci. 18(6): 2084-2096
Hobert, O., Tessmar, K. and Ruvkun, G. (1999). The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development 126: 1547-1562
Irvine, K. D. and Wieschaus, E. (1994). fringe a boundary-specific signaling molecule, mediates interaction between dorsal and ventral cells during Drosophila wing development. Cell 79: 595-606
Johnson, J. D., et al. (1997). Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity. Mol. Cell. Biol. (7): 3488-3496
Jurata, L. W. and Gill, G. N. (1997). Functional analysis of the nuclear LIM domain interactor NLI. Mol. Cell. Biol.17(10): 5688-5698
Kania, A., Johnson, R. L. and Jessell, T. M. (2000). Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. Cell 102: 161-173.
Kim, J. Irvine, K. D and Carroll, S.B. (1995). Cell recognition, signal induction, and symmetrical gene activation at the dorsal/ventral boundary of the developing Drosophila wing. Cell 82: 795-802
Klein, T. and Arias, A. M. (1998). Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development. Development 125(15): 2951-2962
Klein, T., et al. (2000). Two different activities of Suppressor of Hairless during wing development in Drosophila. Development 127: 3553-3566. 10903180
Koelzer, S. and Klein, T. (2006). Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev. Biol. 289(1): 77-90. 16307735
Kojima, T., Tsuji, T. and Saigo, K. (2005). A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. Dev. Biol. 279(2): 434-45. 15733670
Kolterud, A., et al. (2004). The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity. Development 131: 5319-5326. 15456728
Lawrence, P. A. and Struhl, G. (1996). Morphogens, compartments and pattern: Lessons from Drosophila. Cell 85: 951-961
Lu, C., Rincon-Limas, D. E. and Botas, J. (2000). Conserved overlapping and reciprocal expression of msh/Msx1 and apterous/Lhx2 in Drosophila and mice. Mech. Dev. 99(1-2): 177-181.
Lundgren, S. E., Callahan, C. A., Thor, S. and Thomas, J. B. (1995). Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous. Development 121: 1769-1773
Matsuda, H., et al. (2001). An epidermal signal regulates Lmx-1 expression and dorsal-ventral pattern during Xenopus limb regeneration. Dev. Bio. 229: 351-362. 11150239
Milán, M., Diaz-Benjumea, F. J. and Cohen, S. M. (1998). Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function. Genes Dev. 12(18): 2912-2920
Milán, M. and Cohen, S. M. (1999). Regulation of LIM homeodomain activity in vivo: A tetramer of dLDB and Apterous confers activity and capacity for regulation by dLMO. Molecular Cell 4: 267-273
Milán, M. and Cohen, S. M. (2000). Temporal regulation of Apterous activity during development of the Drosophila wing. Development 127: 3069-3078.
Milán, M., et al. (2001a). The LRR proteins Capricious and Tartan mediate cell interactions during DV boundary formation in the drosophila wing. Cell 106: 785-794. 11572783
Milán, P., et al. (2001b). msh specifies dorsal cell fate in the Drosophila wing. Development 128: 3263-3268. 11546743
Milán, M., Pérez, L. and Cohen, S. M. (2002). Short-range cell interactions and cell survival in the Drosophila wing. Dev. Cell 2: 797-805. 12062091
Milán, M. and Cohen, S. M. (2003). A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing. Development 130: 553-562. 12490561
Milán, M., Pham, T. T. and Cohen, S. M. (2004). Osa modulates the expression of Apterous target genes in the Drosophila wing. Mech. Dev. 121: 491-497. 15147766
Mochizuki, T., et al. (2000). Xlim-1 and LIM domain binding protein 1 cooperate with various transcription factors in the regulation of the goosecoid promoter. Dev. Bio. 224: 470-485.
Morcillo, P., et al. (1997). Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila. Genes Dev. 11(20):2729-2740
Nakagawa, Y., Johnson, J. E. and O'Leary, D. D. (1999). Graded and areal expression patterns of regulatory genes and cadherins in embryonic neocortex independent of thalamocortical input. J. Neurosci. 19(24): 10877-85.
Nakagawa, Y. and O'Leary, D. D. M. (2001). Combinatorial expression patterns of LIM-Homeodomain and other regulatory genes parcellate developing thalamus. J. Neurosci. 21(8): 2711-2725. 11306624
Nohno, T., et al. (1997). Differential expression of the two closely related LIM-class homeobox genes LH-2A and LH-2B during limb development. Biochem. Biophys. Res. Commun. 238(2): 506-511
O'Keefe, D. D., Thor, S. and Thomas, J. B. (1998). Function and specificity of LIM domains in Drosophila nervous system and wing development. Development 125(19): 3915-3923
O’Keefe, D. D., and Thomas, J. B. (2001). Drosophila wing development in the absence of dorsal identity. Development 128: 703-710. 11171395
Park, D., Han, M., Kim, Y. C., Han, K. A. and Taghert, P. H. (2004). Ap-let neurons--a peptidergic circuit potentially controlling ecdysial behavior in Drosophila. Dev. Biol. 269(1): 95-108. 15081360
Perea-Gómez, A., et al. (1999). HNF3b and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development 126: 4499-4511. 10498685
Pinto do Oa, P., Kolterud, A. and Carlsson, L. (1998). Expression of the LIM-homeobox gene LH2 generates immortalized Steel factor-dependent multipotent hematopoietic precursors. EMBO J. 17(19): 5744-5756
Porter, F. D., et al. (1997). Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development 124(15): 2935-2944
Pueyo, J. I., et al. (2000). Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1 Development 127: 5391-5402.
Pueyo, J. I. and Couso, J. P. (2004). Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development. Development 131: 3107-3120. 15175252
Rebbert, M. L. and Dawid, I. B. (1997). Transcriptional regulation of the xlim-1 gene by activin is mediated by an element in intron I. Proc. Natl. Acad. Sci. 94(18): 9717-9722
Retaux, S., et al. (1999). Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain. J. Neurosci. 19(2): 783-93
Riddle, R. D., et al. (1995). Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 83: 631-640
Rincon-Limas, D. E., et al. (1999). Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proc. Natl. Acad. Sci. 96(5): 2165-2170
Rincon-Limas, D. E., et al. (2000). The level of DLDB/CHIP controls the activity of the LIM homeodomain protein Apterous: evidence for a functional tetramer complex in vivo. EMBO J. 19: 2602-2614.
Rodriguez-Esteban, C., et al. (1998). Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth. Development 125: 3925-3934
Sagasti, A., et al. (1999). Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 13: 1794-1806
Sanchez-Garcia, I., et al. (1993). The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1. EMBO J. 12: 4243-50
Sharma, K., et al. (1998). LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell 95: 817-828
Shawlot, W., et al. (1999). Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse. Development 126: 4925-4932. 10529411
Sheng, H. Z., et al. (1996). Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. During pituitary organogenesis, the progressive differentiation of distinct pituitary-specific cell lineages from a common primordium involves a series of developmental decisions and inductive interactions. Science 272: 1004-1007
Sockanathan, S. and Jessell, T. M. (1998). Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 94(4): 503-514
Shtorch, A., Werczberger, R. and Segal, D. (1995). Genetic and molecular studies of apterous: a gene implicated in the juvenile hormone system of Drosophila. Arch. Insect Biochem. Physiol. 30: 195-20
Taira, M., Hayes, W. P., Otani, H. and Dawid, I. B. (1993). Expression of LIM class homeobox gene Xlim-3 in Xenopus development is limited to neural and neuroendocrine tissues. Dev Biol 159: 245-56
Taira, M., Saint-Jeannet, J.-P. and Dawid, I. B. (1997). Role of the Xlim-1 and Xbra genes in anteroposterior patterning of neural tissue by the head and trunk organizer. Proc. Natl. Acad. Sci. 94: 895-900
Thor, S. and Thomas, J. B. (1997). The Drosophila islet gene governs axons pathfinding and neurotransmitter identity. Neuron 18: 397-409
Thor, S., Andersson, S. G. E., Tomlinson, A. and Thomas, J. B. (1999). A LIM-homeodomain combinatorial code for motor-neuron pathway selection. Nature 397: 76-80
Tiong, S. Y., Nash, D. and Bender, W. (1995). Dorsal wing, a locus that affects dorsoventral wing patterning in Drosophila. Development 121: 1649-1656. 7600982
Toyama, R., et al. (1995a). The LIM class homeobox gene lim5: implied role in CNS patterning in Xenopus and zebrafish. Dev Biol 170: 583-593
Toyama, R., et al. (1995b). Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Development 121: 383-391
Toyama, R, P., et al. (1998). Expression of LIM-domain binding protein (ldb) genes during zebrafish embryogenesis. Mech. Dev. 71: 197-200
Tremblay, J. J., Lanctot, C. and Drouin, J. (1998). The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3. Mol. Endocrinol. 12(3): 428-41
Tsuchida, T., et al. (1994). Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79: 957-970
Tucker. A. S., et al. (1999). Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development 126(2): 221-228
van Meyel, D. J., et al. (1999). Chip and Apterous physically interact to form a functional complex during Drosophila development. Mol. Cell 4: 259-265
van Meyel, D. J., et al. (2000). Chip is an essential cofactor for Apterous in the regulation of axon guidance in Drosophila. Development 127: 1823-1831. 10751171
van Meyel, D. J., Thomas, J. B. and Agulnick, A. D. (2003). Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. Development 130: 1915-1925. 12642495
Vogel, A., et al. (1995). Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378: 716-720
Wada, S., et al. (1995). Spatially and temporally regulated expression of the LIM class homeobox gene Hrlim suggests multiple distinct functions in development of the ascidian, Halocynthia roretzi. Mech Dev 51: 115-126
Wang, S.-H., Simcox, A. and Campbell, G. (2000). Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development. Genes Dev. 14: 2271-2276.
Weihe, P., Milan, M. and Cohen, S. M. (2001). Regulation of Apterous activity in Drosophila wing development. Development 128: 4615-4622. 11714686
Wenick, A. S. and Hobert, O. (2004). Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans. Dev. Cell 6: 757-770. 15177025
Williams, J. A., Paddock, S.W. and Carroll, S.B. (1993). Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. Development 117: 571-584
Wu, H. K., et al. (1996). Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. Oncogene 12(6): 1205-1212
Wu, H. K. and Minden, M. D. (1997). Transcriptional activation of human LIM-HOX gene hLH-2 in chronic myelogenous leukemia is due to a cis-acting effect of Bcr-Abl. Biochem. Biophys. Res. Commun. 234(3): 742-747
Xu, Y., et al. (1993). LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc. Natl. Acad. Sci. 90(1): 227-231
Xue, D., Tu, Y. and Chalfie, M. (1993) Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3. Science 261: 1324-8
Yamamoto, S., et al. (2003). Molecular link in the sequential induction of the Spemann organizer: direct activation of the cerberus gene by Xlim-1, Xotx2, Mix.1, and Siamois, immediately downstream from Nodal and Wnt signaling. Dev. Biol. 257: 190-204. 12710967
Yan, S.-J., et al. (2004). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development 131: 285-298. 14701680
Zecca, M. and Struhl, G. (2002a). Subdivision of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development 129: 1357-1368. 11880345
Zecca, M. and Struhl, G. (2002b). Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development 129: 1369-1376. 11880346
Zhadanov, A. D., et al. (1995a). Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues. Dev Dyn 202: 354-364
Zhadanov, A. B., et al. (1995b). Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3. Genomics 27: 27-32
Zhao, Y., et al. (1999). Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5. Science 284(5417): 1155-8
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