Beadex
To determine the expression
pattern of Beadex, in situ hybridization was carried out using Beadex cDNA as a probe. In third instar wing imaginal discs,
Beadex is expressed at high levels in the dorsal compartment and at lower levels in the ventral compartment. Beadex
also is expressed in the leg and eye discs. In the embryo, Beadex is expressed in the brain and in a subset of cells in
the developing central nervous system. The presence of Beadex in many different structures suggests that perhaps
dLMO serves multiple functions during development (Zeng, 1998).
Aplan, P. D., et al. (1997). An scl gene product lacking the transactivation domain induces bony
abnormalities and cooperates with LMO1 to generate T-cell malignancies
in transgenic mice. EMBO J. 16(9): 2408-2419.
Boehm, T., Foroni, L., Kennedy, M., and Rabbitts, T.H. (1990). The rhombotin gene belongs to a class of transcriptional regulators with a potential novel protein dimerisation motif. Oncogene 5: 1103--1105.
Chang, D. F., et al. (2003). Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev. Cell 4: 107-118. 12530967
Chen, H. H., et al. (2002). Differential expression of a transcription regulatory factor, the LIM domain only 4 protein Lmo4, in muscle sensory neurons. Development 129: 4879-4889. 12397097
Gering, M., et al. (2003). Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development 130: 6187-6199. 14602685
Grutz, G. G., et al. (1998). The oncogenic T cell LIM-protein lmo2 forms part of a DNA-binding
complex specifically in immature T cells. EMBO J. 17(16): 4594-4605.
Hinks, G. L., et al. (1997). Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse
hippocampus and other forebrain regions: differential regulation by seizure
activity. J. Neurosci. 17(14): 5549-5559.
Kenny, D. A., et al. (1998). Identification and characterization of LMO4, an LMO gene with a novel
pattern of expression during embryogenesis. Proc. Natl. Acad. Sci. 95(19): 11257-11262.
Lai, E. C. and Posakony, J. W. (1997) The Bearded box, a novel 3'UTR sequence motif, mediates
negative post-transcriptional regulation of Bearded and Enhancer of Split complex gene expression.
Development 124: 4847-4856.
Lifschytz, E. and Green, M. M. (1979). Genetic identification of dominant overproducing mutations: the Beadex gene. Molec. gen. Genet. 171: 153-159. 79177917
Manaia, A., et al. (2000). Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites. Development 127(3): 643-653
Mattox, W. W. and Davidson, N. (1984). Isolation and characterization of the Beadex locus of Drosophila
melanogaster: a putative cis-acting negative regulatory element for
the heldup-a gene. Mol. Cell. Biol. 4(7): 1343-1353. 85061239
Mead, P. E., et al. (2001). Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development 128: 2301-2308
Milan, M., Diaz-Benjumea, F. J. and Cohen, S. M. (1998). Beadex encodes an LMO protein that regulates Apterous
LIM-homeodomain activity in Drosophila wing development: a
model for LMO oncogene function. Genes Dev. 12(18): 2912-2920.
Milan, M. and Cohen, S. M. (1999). Regulation of LIM homeodomain activity in vivo: A tetramer
of dLDB and Apterous confers activity and capacity for regulation by dLMO. Molecular Cell 4: 267-273.
Milan, M. and Cohen, S. M. (2000). Temporal regulation of Apterous activity during development of the Drosophila wing. Development 127: 3069-3078.
Milan, M., Pham, T. T. and Cohen, S. M. (2004). Osa modulates the expression of Apterous target genes in the Drosophila wing.
Mech. Dev. 121: 491-497. 15147766
Rorth, P. (1996). A modular misexpression screen in Drosophila detecting tissue specific phenotypes. Proc. Natl. Acad. Sci. 93: 12418-12422.
Rorth, P., et al. (1998). Systematic gain-of-function genetics in Drosophila. Development 125: 1049-1057.
Shoresh, M., et al. (1998). Overexpression Beadex mutations and loss-of-function heldup-a
mutations in Drosophila affect the 3' regulatory and coding components, respectively, of the dlmo gene. Genetics 150(1): 283-299.
Sugihara, T. M., et al. (1998). Mouse deformed epidermal autoregulatory factor 1 recruits a
LIM domain factor, LMO-4, and CLIM coregulators. Proc. Natl. Acad. Sci. 95(26): 15418-23.
Visvader, J. E., et al. (1997). The LIM-domain binding protein ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc. Natl. Acad. Sci. 94(25): 13707-13712.
Wadman, I. A., et al. (1997). The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47,
GATA-1 and Ldb1/NLI proteins. EMBO J (11):3145-3157.
Wang, L. H., Chmelik, R., Tang, D. and Nirenberg, M. (2005). Identification
and analysis of Vnd/NK-2 homeodomain binding sites in genomic DNA. Proc. Natl.
Acad. Sci. 102(20): 7097-102. 15870192
Weihe, P., Milan, M. and Cohen, S. M. (2001). Regulation of Apterous activity in Drosophila wing development. Development 128: 4615-4622. 11714686
Yamada, Y., et al. (1998). The T cell leukemia LIM protein Lmo2 is necessary for adult mouse
hematopoiesis. Proc. Natl. Acad. Sci. 95(7): 3890-3895.
Zeng, C., et al. (1998). The Drosophila LIM-only gene, dLMO, is mutated in beadex alleles
and might represent an evolutionarily conserved function in
appendage development. Proc. Natl. Acad. Sci. 95(18): 10637-10642.
Zhu, T. H., et al (1995). A single ancestral gene of the human LIM domain oncogene family
LMO in Drosophila: characterization of the Drosophila Dlmo gene. Oncogene 11(7): 1283-1290.
Beadex:
Biological Overview
| Evolutionary Homologs
| Regulation
| Developmental Biology
| Effects of Mutation
date revised: 28 June 2005
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