Rho1
Adini, I., et al. (2003). RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev. 17: 2721-2732. 14597666
Aijaz, S., D'Atri, F., Citi, S., Balda, M. S. and Matter, K. (2005). Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. Dev. Cell 8(5): 777-86. 15866167
Alberts, A. S., Geneste, O. and Treisman, R. (1998a). Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell 92: 475-487.
Alberts, A. S. and Treisman, R. (1998b). Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1. EMBO J. 17(14): 4075-4085.
Altun-Gultekin, Z. F., et al. (1998). Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein. Mol. Cell. Biol. 18(5): 3044-3058.
Amano, M., et al. (1996). Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271(34): 20246-20249.
Amano, M., et al. (1997). Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275(5304): 1308-1311.
Anastasiadis, P. Z., Moon, S. Y., Thoreson, M. A., Mariner, D. J., Crawford, H. C., Zheng, Y. and Reynolds, A. B. (2000). Inhibition of RhoA by p120 catenin. Nature Cell Biol. 2: 637-644. 10980705
Appel, L.F., Prout, M., Abu-Shumays, R., Hammonds, A., Garbe, J.C., Fristrom, D., and Fristrom, J. (1993). The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Proc. Natl. Acad. Sci. 90: 4937-4941. 6289325
Aspenstrom, P., Richnau, N. and Johansson, A. S. (2006). The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Exp Cell Res. 312(12): 2180-94. 16630611
Atfi A., et al. (1997). Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. J. Biol. Chem. 17;272(3): 1429-1432.
Audhya, A. and Emr, S. D. (2002). Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Developmental Cell 2: 593-605. 12015967
Banerjee, J. and Wedegaertner, P. B. (2004). Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. Mol. Biol. Cell 15(4): 1760-75. Medline abstract: 14742719
Barrett, K., Leptin, M. and Settleman, J. (1997). The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell 91(7): 905-915. Medline abstract: 9428514
Bashaw, G. J., Hu, H., Nobes, C. D. and Goodman, C. S. (2001). A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion. J. Cell Bio. 155: 1117-1122. 11756465
Besson, A., et al. (2004). p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18: 862-876. 15078817
Billuart, P., Winter, C. G., Maresh, A., Zhao, X. and Luo, L. (2001). Regulating axon branch stability. the role of p190 RhoGAP in repressing a retraction signaling pathway. Cell 107(2): 195-207. 11672527
Birkenfeld, J., et al. (2007). GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev. Cell 12(5): 699-712. PubMed citation: 17488622
Bito, H., et al. (2000). A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 26: 431-441.
Bloor, J. W. and Kiehart, D. P. (2001). zipper nonmuscle Myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. Dev. Bio. 239: 215-228
Bloor, J. W. and Kiehart, D. P. (2002). Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. Development 129: 3173-3183. 12070092
Boutros, M., et al. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94(1): 109-118.
Brouns, M. R., et al. (2000). The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development 127: 4891-4903. 11044403
Brouns, M. R., Matheson, S. F. and Settleman, J. (2001). p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat. Cell Biol. 3: 361-367. 11283609
Burbelo, P. D., et al. (1995). p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J. Biol. Chem. 270(52):30919-30926.
Cali G., et al. (1999). RhoA activity is required for fibronectin assembly and counteracts beta1B integrin inhibitory effect in FRT epithelial cells. J. Cell Sci. 112 ( Pt 6): 957-65.
Carnac, G., et al. (1998). RhoA GTPase and serum response factor control selectively the expression of MyoD without affecting myf5 in mouse myoblasts. Mol. Biol. Cell 9(7): 1891-1902.
Causeret, F., et al. (2004). Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1. Development 131: 2841-2852. 15151987
Cen, B., Selvaraj, A., Burgess, R. C., Hitzler, J. K., Ma, Z., Morris, S. W. and Prywes, R. (2003). Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol. Cell. Biol. 23: 6597-6608. 12944485
Chang, J. H., et al. (1998). The small GTP-binding protein Rho potentiates AP-1 transcription in T cells. Mol. Cell. Biol. 18(9): 4986-93.
Chen, G-C., Gajowniczek, P. and Settleman, J. (2004). Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Current Biol. 14: 309-313. 14972681
Chen, G. C., et al. (2005). Regulation of Rho and Rac signaling to the actin cytoskeleton by Paxillin during Drosophila development. Molec. Cell. Biol. 25: 979-987. 15657426
Chihara, K., et al. (1997). Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase. J. Biol. Chem. 272(40): 25121-25127.
Chong, L. D., et al. (1994). The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79(3): 507-13.
Cid, V. J., et al. (1998). A mutation in the Rho1-GAP-encoding gene BEM2 of Saccharomyces cerevisiae affects morphogenesis and cell wall functionality. Microbiology 144( Pt 1): 25-36.
Clark, E. A., et al. (1998). Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142(2): 573-86.
Clark, E. A., et al. (2000). Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406: 532-535.
Clayton, L., Hall, A. and Johnson, M. H. (1999). A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres. Dev. Biol. 205(2): 322-331.
Cook, T. A., et al. (1998). Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid. J. Cell Biol. 141(1): 175-185.
Costa, M., Wilson, E. T. and Wieschaus, E. (1994). A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell 76 (6): 1075-1089. Medline abstract: 8137424
Cox, E. A., Sastry, S. K. and Huttenlocher, A. (2001). Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the rho family of GTPases. Mol. Biol. Cell 12: 265-277. 11179414
Crawford, J. M., et al. (1998). Cellularization in Drosophila melanogaster is disrupted by the inhibition of Rho activity and the activation of Cdc42 function. Dev. Biol. 204(1): 151-64.
Dadke, D., Jarnik, M., Pugacheva, E. N., Singh, M. K. and Golemis, E. A. (2006). Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol. Biol. Cell 17(3): 1204-17. 16394104
Dalpé, G., et al. (2004). Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans. Development 131: 2073-2088. 15073148
Danen, E. H., et al. (2000). Dual stimulation of Ras/Mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression. J. Cell Biol. 151(7): 1413-1422. 11134071
D'Avino, P. P., Savoian, M. S. and Glover, D. M. (2004). Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. J. Cell Biol. 166(1):61-71. 15240570
Dean, S. O., Rogers, S. L., Stuurman, N., Vale, R. D. and Spudich, J. A. (2005). Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc. Natl. Acad. Sci. 102(38): 13473-8. 16174742
Debant, A., et al. (1996). The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl. Acad. Sci. 93(11): 5466-5471.
de Bettignies, G., et al. (2001). Overactivation of the Protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae. Genetics 159: 1435-1448. 11779787
Deng, X., et al. (2003). Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation. J. Biol. Chem. 278(42): 41347-54. 12902328
Denholm, B., Brown, S., Ray, R. P., Ruiz-Gomez, M., Skaer, H and Hombria, J. C. (2005). crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis. Development 132(10): 2389-400. 15843408
Derewenda, U., et al. (2004). The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle. Structure 12(11): 1955-65. Medline abstract: 15530360
Di Cunto, F., et al. (1998). Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. J. Biol. Chem. 273(45): 29706-11.
Diogon, M., et al. (2007). The RhoGAP RGA-2 and LET-502/ROCK achieve a balance of actomyosin-dependent forces in C. elegans epidermis to control morphogenesis. Development 134: 2469-2479. Medline abstract: 17537791
Dong, J. M., et al. (1998). cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha. J. Biol. Chem. 273(35): 22554-22562.
Estrach, S., et al. (2002). The human Rho-GEF Trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth. Curr. Biol. 12: 307-312. 11864571
Fanto, M., et al. (2000). Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr. Biol. 10: 979-988
Fincham, V. J., Chudleigh, A. and Frame, M. C. (1999). Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. J. Cell Sci. 112 ( Pt 6): 947-56.
Fox, D. T., Homem, C. C., Myster, S. H., Wang, F., Bain, E. E. and Peifer, M. (2005). Rho1 regulates Drosophila adherens junctions independently of p120ctn. Development 132(21): 4819-31. 16207756
Fox, D. T. and Peifer, M. (2007). Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134(3): 567-78. Medline abstract: 17202187
Fritz, J. L. and VanBerkum, M. F. A. (2002). Regulation of rho family GTPases is required to prevent axons from crossing the midline. Dev. Bio. 252: 46-58. 12453459
Fujisawa, K., et al. (1996). Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase. J. Biol. Chem. 271(38): 23022-23028.
Fukuhara, S., et al. (1999). A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J. Biol. Chem. 274(9): 5868-79.
Furuyashiki, T., et al. (1999). Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. J. Neurosci. 19(1): 109-18.
Geneste, O., Copeland, J.W., and Treisman, R. (2002). LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics. J. Cell Biol. 157: 831-838. 12034774
Gohla, A., Harhammer, R., and Schultz, G. (1998). The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J. Biol. Chem. 273(8): 4653-4659.
Grosshans, J., Wenzl, C., Herz, H. M., Bartoszewski, S., Schnorrer, F., Vogt, N., Schwarz, H. and Muller, H. A. (2005). RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation. Development 132(5): 1009-20. 15689371
Guo, W., Tamanoi, F. and Novick, P. (2001). Spatial regulation of the exocyst complex by Rho1 GTPase. Nat. Cell Biol. 3: 353-360. 11283608
Habas, R., Kato, Y. and He, X. (2001). Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel formin homology protein Daam1. Cell 107: 843-854. 11779461
Hacker, U. and Perrimon, N. (1998). DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 12: 274-284.
Halsell, S. R., Chu, B. I. and Kiehart, D. P. (2000). Genetic analysis demonstrates a direct link between Rho signaling and nonmuscle myosin function during Drosophila morphogenesis. Genetics 155: 1253-1265.
Harden, N., et al. (1999). Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J. Cell Sci. 112: 273-84. 99104229
Hariharan, I. K., et al. (1995). Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect. EMBO J 14 (2): 292-302.
Hart, M. J., et al. (1998). Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science 280(5372): 2112-2114.
Helliwell, S. B., et al. (1998). The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton. Curr. Biol. 8(22): 1211-4.
Heo, W. D. and Meyer, T. (2003). Switch-of-function mutants based on morphology classification of ras superfamily small GTPases. Cell 113: 315-328. 12732140
Hicks, M. S., et al. (2001). DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern. Dev Genes Evol: 211: 263-267. 11455443
Hickson, G. R. and O'Farrell, P. H. (2008). Rho-dependent control of anillin behavior during cytokinesis. J. Cell Biol. 180(2): 285-94. PubMed citation: 18209105
Hildebrand, J. D., Taylor, J. M. and Parsons, J. T. (1996). An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol. Cell. Biol. 16(6): 3169-3178.
Hill, C. S., Wynne, J. and Treisman, R. (1995). The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81(7): 1159-1170.
Homem, C. C. F. and Peifer, M. (2008). Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis. Development 135: 1005-1018. PubMed Citation: 18256194
Hornstein, I., Mortin, M. A. and Katzav, S. (2003). DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways. Oncogene 22: 6774-6784. PubMed citation: 14555990
Hu, H., Marton, T. F. and Goodman, C. S. (2001). Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron 32: 39-51. 11604137
Imamura, H., et al. (1998). Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells. Mol. Biol. Cell 9(9): 2561-75.
Ishizaki, T, et al. (1996). The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15(8): 1885-1893.
Ishizaki, T., et al. (1997). p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett. 404(2-3): 118-124.
Jacinto, A., et al. (2002). Dynamic analysis of actin cable function during Drosophila dorsal closure. Curr. Biol. 12: 1245-1250. 12176336
Jaffe, A. B., Aspenstrom, P. and Hall, A. (2004). Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Mol. Cell Biol. 24(4): 1736-46. 14749388
Jaffe, A. B., Hall, A. and Schmidt, A. (2005). Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. Curr. Biol. 15(5): 405-12. 15753034
Jou, T. S. and Nelson, W. J. (1998a). Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol. 142(1): 85-100.
Jou, T. S, Schneeberger, E. E. and Nelson, W. J. (1998b). Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 142(1): 101-15.
Kawano, Y., et al. (1999). Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J. Cell Biol. 147(5): 1023-38.
Kimura, K., et al. (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273(5272): 245-8.
Klages, B., et al. (1999). Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J. Cell Biol. 144(4): 745-754.
Kolesnikov, T. and Beckendorf, S. K. (2007). 18 wheeler regulates apical constriction of salivary gland cells via the Rho-GTPase-signaling pathway. Dev. Biol. 307(1): 53-61. Medline abstract: 17512518
Koyano, Y., et al (1997). Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors. Biochem. Biophys. Res. Commun. 241(2): 369-375.
Kozasa, T., et al. (1998). p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science 280(5372): 2109-2111.
Krugmann, S., et al. (2004). ARAP3 is a PI3K- and Rap-Regulated GAP for RhoA. Curr. Biol. 14: 1380-1384. 15296756
Kumakiri, J., et al. (2003). Involvement of Rho family G protein in the cell signaling for sperm incorporation during fertilization of mouse eggs: inhibition by Clostridium difficile toxin B. Dev. Bio. 260: 522-535. 12921750
Kureishi, Y., et al. (1997). Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J. Biol. Chem. 272(19): 12257-12260.
Kwan, K. M. and Kirschner, M. W. (2005). A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development 132(20): 4599-610. 16176947
Latham, V. M., et al. (2001). A Rho-dependent signaling pathway operating through myosin localizes ß-actin mRNA in fibroblasts. Cur. Bio. 11: 1010-1016. 11470405
Leblanc, V., Tocque, B. and Delumeau, I. (1998). Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain. Mol. Cell. Biol. 18(9): 5567-78.
Lee, S. and Kolodziej, P. A. (2002). The plakin Short stop and the RhoA GTPase are required for E-cadherin-dependent apical surface remodeling during tracheal tube fusion. Development 129: 1509-1520. 11880359
Lee, S. and Helfman, D. M. (2003). Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/Cofilin pathway. J. Biol. Chem. 279: 1885-1891. 14559914
Lee, T., et al. (2000). Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis. Neuron 25: 307-316.
Lehmann, M., et al. (1999). Inactivation of Rho signaling pathway promotes CNS axon regeneration. J. Neurosci. 19(17): 7537-7547.
Leverrier, Y. and Ridley, A. J. (2001). Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages. Curr. Biol. 11: 195-199. 11231156
Li, Z., Aizenman, C. D. and Cline, H. T. (2002). Regulation of Rho GTPases by crosstalk and neuronal activity in vivo. Neuron 33: 741-750. 11879651
Liu, J. P. and Jessell, T. M. (1998). A role for rhoB in the delamination of neural crest cells from the dorsal neural tube. Development 125(24): 5055-5067.
Lopez-Ilasaca, M. A., Bernabe-Ortiz, J. C., Na, S. Y., Dzau, V. J. and Xavier, R. J. (2005). Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. FEBS Lett. 579(3): 648-54. 15670823
Lu, J., et al. (2001). Coronary smooth muscle differentiation from proepicardial cells requires RhoA-mediated actin reorganization and p160 Rho-kinase activity. Dev. Biol. 240(2): 404-418. 11784072
Lu, Y. and Settleman, J. (1999). The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Genes Dev. 13(9): 1168-80.
Lutz, S., et al. (2007). Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science 318(5858): 1923-7. PubMed citation: 18096806
Maekawa, M., et al. (1999). Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase Science 285(5429): 895-8.
Magie, C. R., et al. (1999). Mutations in the Rho1 small GTPase disrupt morphogenesis and segmentation during early Drosophila development Development 126: 5353-5364.
Magie, C. R., Pinto-Santini, D. and Parkhurst, S. M. (2002). Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development 129: 3771-3782. 12135916
Magie, C. R. and Parkhurst, S. M. (2005). Rho1 regulates signaling events required for proper Drosophila embryonic development. Dev. Biol. 278(1): 144-54. 15649467
Manning, B. D., Padmanabha, R. and Snyder, M. (1997). The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Mol. Biol. Cell 8(10): 1829-1844.
Mao, J., et al. (1998a). Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. EMBO J. 17(19): 5638-5646.
Mao, J., et al. (1998b). Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. Proc. Natl. Acad. Sci. 95(22): 12973-6.
Marquitz, A. R., et al. (2002). The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint. EMBO J. 21: 4012-4025. 16469972 uids=12145202&dopt=Abstract">12145202
Matsui, T., et al. (1998). Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association. J. Cell Biol. 140(3):647-657.
Matsui, T., et al. (2005). Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev. 19(1): 164-75. 15630025
McBeath, R., et al. (2003). Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 6: 483-495. 15068789
McMullan, R., et al. (2004). Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr. Biol. 13: 2185-2189. 14680635
Michaelson, D., et al. (2001). Differential localization of Rho GTPases in live cells. Regulation by hypervariable regions and rhoGDI binding. J. Cell Biol. 152(1): 111-126. 11149925
Ming, G. L., et al. (1997). cAMP-dependent growth cone guidance by Netrin-1. Neuron 19(6): 1225-1235.
Minoshima, Y., et al. (2003). Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Developmental Cell 4: 549-560. 12689593
Miralles, F., Posern, G., Zaromytidou, A.I. and Treisman, R. (2003). Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113: 329-342. 12732141
Mizuno, T., Amano, M., Kaibuchi, K. and Nishida, Y. (1999). Identification and characterization of Drosophila homolog of Rho-kinase. Gene 238(2): 437-444. 10570971
Murphy, A. M. and Montell, D. J. (1996). Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J. Cell Biol. 133: 617-630.
Myster, S. H., Cavallo, R., Anderson, C. T., Fox, D. T. and Peifer, M. (2003). Drosophila p120 catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. J. Cell Biol. 160: 433-449. 12551951
Nakahara, H., et al. (1998). Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia. J. Biol. Chem. 273(1): 9-12.
Niiya, F., Xie, X., Lee, K. S., Inoue, H. and Miki, T. (2005). Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. J. Biol. Chem. 280(43): 36502-9. 16118207
Niiya, F., et al. (2006). Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. Oncogene 25: 827-837. PubMed citation: 16247472
Nikolaidou, K. K. and Barrett, K. (2004). A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation. Curr. Biol. 14: 1822-1826. 15498489
Nishimura, Y. and Yonemura, S. (2006). Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J. Cell Sci. 119: 104-114. PubMed citation: 16352658
Nobes, C. D., et al. (1998). A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J. Cell. Biol. 141(1): 187-197.
Nolan, K.M., et al. (1998). Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a rac signaling pathway utilized for multiple developmental processes. Genes Dev. 12: 3337-3342.
Noren, N. K., Liu, B. P., Burridge, K. and Kreft, B. (2000). p120ctn regulates the actin cytoskeleton via Rho family GTPases. J. Cell Biol. 150: 567-57. 10931868
O'Connell, C. B., et al. (1999). The small GTP-binding protein rho regulates cortical activities in cultured cells during division. J. Cell Biol. 144(2): 305-13.
Olson, M. F., Paterson, H. F. and Marshall, C. J. (1998). Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394: 295-299.
Otomo, T., Otomo, C., Tomchick, D. R., Machius, M. and Rosen, M. K. (2005). Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol. Cell 18: 273-281. 15866170
Padash Barmchi, M., Rogers, S. and Hacker, U. (2005). DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo. J. Cell Biol. 168: 575-585. 15699213
Panizzi, J. R., et al. (2007). New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia. Development 134: 921-931. Medline abstract: 17267448
Parnas, D., Haghighi, A. P., Fetter, R. D., Kim, S. W. and Goodman, C. S. (2001). Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Neuron 32(3): 415-24. 11709153
Perrot, V., Vazquez-Prado, J., Gutkind, J. S. (2002). Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J. Biol. Chem. 277(45): 43115-20. Medline abstract: 12183458
Prokopenko, S. N., Saint, R. and Bellen, H. J. (2000). Tissue distribution of PEBBLE RNA and Pebble protein during Drosophila embryonic development. Mech. Dev. 90: 269-273.
Quilliam, L. A., et al. (1996). Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J. Biol. Chem. 271(46): 28772-28776.
Raghavan, S., Vaezi, A. and Fuchs, E. (2003). A role for alphaß1 integrins in focal adhesion function and polarized cytoskeletal dynamics. Dev. Cell 5: 415-427. 12967561
Raymond, K., et al. (2004). A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis. J. Cell Sci. 117(Pt. 13): 2777-2789. 15169836
Ren, X. D. and Schwartz, M. A. (1998). Regulation of inositol lipid kinases by Rho and Rac. Curr. Opin. Genet. Dev. 8(1): 63-7.
Ren, X. D., Kiosses, W. B. and Schwartz, M. A. (1999). Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18(3): 578-585.
Reverte, C. G., et al. (2003). XGef is a CPEB-interacting protein involved in Xenopus oocyte maturation. Dev. Bio. 255: 383-398. 12648498
Ricos, M. G., et al. (1999). Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. J. Cell Sci. 112: 1225-35.
Rittinger, K., et al. (1997). Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature 388(6643): 693-697.
Rosales-Nieves, A. E., et al. (2006). Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino. Nat. Cell Biol. 8(4): 367-76. 16518391
Rose, R., Weyand, M., Lammers, M., Ishizaki, T., Ahmadian, M. R. and Wittinghofer, A. (2005). Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature 435: 513-518. 15864301
Sahai, E., Alberts, A. S. and Treisman, R. (1998). RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. Embo J. 17(5): 1350-1361.
Sahai, E., et al. (1999). Transformation mediated by RhoA requires activity of ROCK kinases. Curr. Biol. 9(3): 136-45.
Sahai, E., Olson, M. F. and Marshall, C. J. (2001). Cross-talk between Ras and Rho signaling pathways in transformation favours proliferation and increased motility. EMBO J. 20: 755-766. 11179220
Sanders, L. C., et al. (1999). Inhibition of myosin light chain kinase by p21-activated kinase. Science 283(5410): 2083-5.
Saras, J., et al. (1997). A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1. J. Biol. Chem. 272(39): 24333-24338.
Sarkar, A., et al. (2007). Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Curr. Biol. 17(14): 1253-8. PubMed citation: 17629483
Sasamura, T., et al. (1997). Molecular cloning and characterization of Drosophila genes encoding small GTPases of the rab and rho families. Mol. Gen. Genet. 254(5): 486-494.
Schock, F. and Perrimon, N. (2002). Cellular processes associated with germ band retraction in Drosophila. Dev. Bio. 248: 29-39. 12142018
Schoenwaelder, S. M., et al. (2000). The protein tyrosine phosphatase Shp-2 regulates RhoA activity. Curr. Biol. 10: 1523-1526. 11114521
Schonegg, S. and Hyman, A. A. (2006). CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos. Development 133: 3507-3516. Medline abstract: 16899536
Schonegg, S., Constantinescu, A. T., Hoege, C. and Hyman, A. A. (2007). The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos. Proc. Natl. Acad. Sci. 104(38): 14976-81. Medline abstract: 17848508
Schuebel, K. E., et al. (1998). Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J. 17(22): 6608-21.
Sepp, K. J. and Auld, V. J. (2003). RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia. Development 130: 1825-1835. 12642488
Shandala, T., et al. (2004). Citron Kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster. Development 131: 5053-5063. 15459099
Shaw, R. J., et al. (1998). RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Mol. Biol. Cell 9(2): 403-419.
Shibasaki, Y., et al. (1997). Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo. J. Biol. Chem. 272(12): 7578-81.
Simoes, S., et al. (2006). Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Development 133: 4257-4267. Medline abstract: 17021037
Sin, W. C., et al., (1998). RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network. Mol. Cell. Biol. 18(11): 6325-39.
Sin, W. C., et al. (2002). Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases. Nature 419: 475-480. 12368855
Somma, M. P., et al. (2002). Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol. Biol. Cell 13: 2448-2460. 12134082
Song, H.-J., Ming, G.-L. and Poo, M.-M. (1997). cAMP-induced switching in turning direction of nerve growth cones. Nature 388: 275-279.
Sordella, R., et al. (2003). Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 113: 147-158. 12705864
Sotiropoulos, A., Gineitis, D., Copeland, J. and Treisman, R. (1999). Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell 98: 159-169. 10428028
Speck, O., Hughes, S. C., Noren, N. K., Kulikauskas, R. M. and Fehon, R. G. (2003). Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature 421(6918): 83-7. 12511959
Storey, N. M., O'Bryan, J. P. and Armstrong, D. L. (2002). Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr. Biol. 12: 27-33. 11790300
Strutt, D. I., Weber. U., and Mlodzik, M. (1997). The role of RhoA in tissue polarity and Frizzled signalling. Nature 387 (6630): 292-295.
Strutt, D., Johnson, R., Cooper, K. and Bray, S. (2002). Asymmetric localization of Frizzled and the determination of Notch-dependent cell fate in the Drosophila eye. Curr. Biol. 12: 813-824. 12015117
Sumi, T., et al. (1999). Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J. Cell. Biol. 147: 1519-1532. 10613909
Tahinci, E. and Symes, K. (2003). Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation. Dev. Biol. 259: 318-335. 12871704
Takano, H., et al. (1998). The Rho family G proteins play a critical role in muscle differentiation. Mol. Cell. Biol. 18(3): 1580-1589.
Tanaka, H., Yamashita, T., Asada, M., Mizutani, S., Yoshikawa, H. and Tohyama, M. (2002). Cytoplasmic p21Cip1/Waf1 regulates neurite remodeling by inhibiting Rho-kinase activity. J. Cell. Biol. 158: 321-329. 12119358
Tanaka, K., Okubo, Y. and Abe, H. (2005). Involvement of slingshot in the Rho-mediated dephosphorylation of ADF/cofilin during Xenopus cleavage. Zoolog. Sci. 22(9): 971-84. 16219977
Tanaka, M., et al. (2003). Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. EMBO J. 22: 847-858. 12574121
Taylor, J. M., et al. (1999). Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. J. Cell Sci. 112: 231-42.
Tatsumoto, T., Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I. and Miki, T. (1999). Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J. Cell Biol. 147(5): 921-8.
Tolliday, N., VerPlank, L. and Li, R. (2002). Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis. Curr. Biol. 12: 1864-1870. 12419188
Tominaga, T., et al. (1998). p160ROCK mediates RhoA activation of Na-H exchange. EMBO J. 17(16): 4712-4722.
Vidal, M., Larson, D. E. and Cagan, R. L. (2006). Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev. Cell 10: 33-44. PubMed citation: 16399076
Wahl, S., et al. (2000). Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J. of Cell Biol. 149: 263-270.
Watanabe, G., et al. (1996). Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science 271(5249): 645-648.
Watanabe, N., et al. (1997). p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 16(11): 3044-3056.
Watanabe, N., et al. (1999). Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat. Cell Biol. 1: 136-143.
Wei, L., et al. (2002). Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development 129: 1705-1714. 11923206
Wei, L., et al. (2001). Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Development 128: 2953-2962. 11532918
Weiner, O. D., et al. (2002). A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity, Nat. Cell Biol. 4: 509-513. Medline abstract: 12080346
Wellington, A., et al. (1999). Spire contains actin binding domains and is related to ascidian posterior end mark-5. Development 126: 5267-5274.
Wen, Y., et al. (2004). EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. Nat. Cell Biol. 6(9): 820-30. 15311282
Werner, L. A. and Manseau, L. J. (1997). A Drosophila gene with predicted rhoGEF, a pleckstrin homology and SH3 domains is highly expressed in morphogenic tissues. Gene 187: 107-114.
Winter, C. G., et al. (2001). Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105: 81-91. 11301004
Wissmann, A., et al. (1997). Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape. Genes Dev. 11: 409-422.
Wissmann, A., Ingles, J. and Mains, P. E. (1999). The Caenorhabditis elegans mel-11 Myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the Rac signaling pathway. Dev. Biol. 209(1): 111-127.
Wu, W. J., et al. (1997). Interaction between Cdc42Hs and RhoGDI is mediated through the Rho insert region. J. Biol. Chem. 272(42): 26153-26158.
Wunnenberg-Stapleton, K., et al. (1999). Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development. Development 126(23): 5339-5351.
Yokoo, T., Toyoshima, H., Miura, M., Wang, Y., Iida, K. T., Suzuki, H., Sone, H., Shimano, H., Gotoda, T., Nishimori, S., et al. (2003). p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus. J. Biol. Chem. 278: 52919-52923. 14530263
Yoshizaki, H., et al. (2004). Cell type-specific regulation of RhoA activity during cytokinesis. J. Biol. Chem. 279(43): 44756-62. 15308673
Zhai, J., Lin, H., Nie, Z., Wu, J., Canete-Soler, R., Schlaepfer, W. W. and Schlaepfer, D. D. (2003). Direct interaction of focal adhesion kinase with p190RhoGEF. J. Biol. Chem. 278: 24865-24873. Medline abstract: 12702722
Zhang, W., et al. (1999). Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J. Neurosci. 19(1): 96-108.
Zheng, Y., et al. (1996). The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting. J. Biol. Chem. 271(32): 19017-19020.
Zhong. C., et al. (1998). Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. J. Cell. Biol. 141(2): 539-551.
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