Rac1

Nakaya, Y., Kuroda, S., Katagiri, Y. T., Kaibuchi, K. and Takahashi Y. (2004). Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell. 7(3): 425-38. 15363416

Newsome, T. P., Schmidt, S., Dietzl, G., Keleman, K., Asling, B., Debant, A., and Dickson, B. J. (2000). Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell 101: 283-94.

Ng, J., et al. (2002). Rac GTPases control axon growth, guidance and branching. Nature 416: 442-447. 11919635

Ng, J. and Luo, L. (2004). Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron 44: 779-793. 15572110

Nikolic, M., et al. (1998). The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature 395(6698): 194-8.

Nisimoto, Y., et al. (1997). Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase. J. Biol. Chem. 272(30): 18834-18841.

Nobes, C. D. and Hall, A. (1995a). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81 (1): 53-62.

Nobes, C. D., et al. (1995b). Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci. 108 ( Pt 1): 225-233.

Nolan, K. M., et al. (1998). Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev. 21: 3337-3342

Norman, J. C., et al. (1996). The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways. Mol Biol Cell 7 (9): 1429-1442.

Obermeier, A., et al. (1998). PAK promotes morphological changes by acting upstream of Rac. EMBO J. 17: 4328-4339

Olofsson, B. and Page, D. T. (2005). Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity. Dev. Biol. 279(1): 233-43. 15708571

Olson, M. F., Ashworth, A., and Hall, A. (1995). An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269: 1270-1272.

Paglini, G., et al. (1998). Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth. J Neurosci 18(23): 9858-9869

Patrick, G. N., et al. (1998). p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J. Biol. Chem. 273(37): 24057-64.

Penzes, P., et al. (2003). Rapid induction of dendritic spine morphogenesis by trans-synaptic EphrinB-EphB receptor activation of the Rho-GEF Kalirin. Neuron 37: 263-274. 12546821

Perona, R., et al. (1997). Activation of the nuclear factor-KB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 11: 463-475.

Pirraglia, C., Jattani, R. and Myat, M. M. (2006). Rac function in epithelial tube morphogenesis. Dev. Bio. 290: 435-446. 16412417

Potempa, S. and Ridley, A. J. (1998). Activation of both MAP kinase and Phosphatidylinositide 3-kinase by Ras Is required for Hepatocyte growth factor/Scatter factor-induced adherens junction disassembly. Mol. Biol. Cell 9(8): 2185-2200.

Price, L. S., et al. (1998). Activation of rac and cdc42 by integrins mediates cell spreading. Mol. Biol. Cell 9(7): 1863-1871.

Qi, Z., et al. (1998). Association of neurofilament proteins with neuronal Cdk5 activator. J. Biol. Chem. 273(4): 2329-35.

Qiu, R.-G., Abo, A. and Martin, G. S. (2000). A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation. Curr. Biol. 10: 697-707.

Raymond, K., et al. (2004). A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis. J. Cell Sci. 117(Pt. 13): 2777-2789. 15169836

Reddien, P. W. and Horvitz, H. R. (2000). CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat. Cell Biol. 2(3): 131-6. 10707082

Reif, K., et al. (1996). Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr Biol 6: 1445-1455.

Ricos, M. G., et al. (1999). Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. J. Cell Sci. 112: 1225-35.

Ridley, A. J. and Hall, A. (1992a). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70(3), 389-399.

Ridley, A. J., et al. (1992b). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70 (3): 401-410.

Roux, P., et al. (1997). The small GTPases Cdc42Hs, rac1 and RhoG delineate raf-independent pathways that cooperate to transform NIH3T3 cells. Curr. Biol. 7(9): 629-637.

Saneyoshi, T., et al. (2008). Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/βPIX signaling complex. Neuron 57(1): 94-107. PubMed citation: 18184567

Sarkar, A., et al. (2007). Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Curr. Biol. 17(14): 1253-8. PubMed citation: 17629483

Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J. L. and Giangrande, A. (2003). CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron 38: 887-898. 12818175

Sells, M. A., Boyd, J. T. and Chernoff, J. (1999). p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J. Cell Biol. 145(4): 837-849

Sepp, K. J. and Auld, V. J. (2003). RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia. Development 130: 1825-1835. 12642488

Sharma, P., et al. (1998). Site-specific phosphorylation of Lys-Ser-Pro repeat peptides from neurofilament H by cyclin-dependent kinase 5: structural basis for substrate recognition. Biochemistry 37(14): 4759-66.

Shaw, R. J., et al. (2001). The Nf2 tumor suppressor, merlin, functions in rac-dependent signaling. Dev. Cell 1: 63-72

Shuang, R., et al. (1998). Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings. J. Biol. Chem. 273(9): 4957-66.

Sini, P., Cannas, A., Koleske, A. J., Di Fiore, P. P. and Scita, G. (2004). Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation. Nat. Cell. Biol. 6: 268-274. 15039778

Skorski, T., et al. (1998). BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac. Proc. Natl. Acad. Sci. 95(20): 11858-62.

Sone, M., et al. (1997). Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers. Science 275(5299): 543-547.

Sone, M., et al. (2000). Synaptic development is controlled in the periactive zones of Drosophila synapses. Development 127: 4157-4168

Sotillos, S. and Campuzano, S. (2000). DRacGAP, a novel Drosophila gene, inhibits Egfr/Ras signaling in the developing imaginal wing disc. Development 127: 5427-5438.

Srahna, M., Leyssen, M., Choi, C. M., Fradkin, L. G., Noordermeer, J. N. and Hassan, B. A. (2006). A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 4(11): e348. Medline abstract: 17032066

Stappenbeck, T. S. and Gordon, J. I. (2000). Rac1 mutations produce aberrant epithelial differentiation in the developing and adult mouse small intestine. Development 127: 2629-2642.

Stappenbeck, T. S. and Gordon, J. I. (2001). Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice. Development 128: 2603-2614. 11493576

Steffen, A., Rottner, K., Ehinger, J., Innocenti, M., Scita, G., Wehland, J. and Stradal, T. E. (2004). Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J. 23: 749-759. 14765121

Steven, R., et al. (1998). UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92(6): 785-795.

Storey, N. M., O'Bryan, J. P. and Armstrong, D. L. (2002). Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr. Biol. 12: 27-33. 11790300

Struckhoff, E. C. and Lundquist, E. A. (2003). The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegans. Development 130: 693-704. 12506000

Su, Y.-C. Treisman, J. E. and Skolnik, E. Y. (1998). The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway. Genes Dev. 12: 2371-2380

Tahinci, E. and Symes, K. (2003). Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation. Dev. Biol. 259: 318-335. 12871704

Takahashi, K., et al. (1998). Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the Jun N-terminal kinase pathway in Drosophila morphogenesis. Mech. Dev. 78(1-2): 97-111.

Takano, H., et al. (1998). The Rho family G proteins play a critical role in muscle differentiation. Mol. Cell. Biol. 18(3): 1580-1589.

Takesono, A., et al. (2004). Requirement for tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr. Biol. 14: 917-922. 15186750

Tang, Y., et al. (1997). Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol. Cell. Biol. 17: 4454-4464.

Tang, Y., Yu, J. and Field, J. (1999). Signals from the ras, rac, and rho GTPases converge on the pak protein kinase in rat-1 fibroblasts. Mol. Cell. Biol. 19(3): 1881-91.

Tapon, N, and Hall, A. (1997). Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol. 9: 86-92.

Tapon, N., Nagata, K., Lamarche, N. and Hall, A. (1998). A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J. 17(5): 1395-404. 9482736

Teramoto, H., et al. (1996). Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J Biol Chem 271 (44): 27225-27228.

Timpson, P., et al. (2001). Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity. Curr. Biol. 11: 1836-1846. 11728306

Tolias, K. F., Cantley, L. C. and Carpenter, C. L. (1995). Rho family GTPases bind to phosphoinositide kinases. J. Biol. Chem. 270(30): 17656-9.

Tolias, K. F., et al. (1998). Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Mol. Cell. Biol. 18(2): 762-770.

Tolias, K. F., et al. (2000). Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr. Biol. 10: 153-156.

Tolias, K. F., et al. (2005). The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron 45(4): 525-38. 15721239

Tolkacheva, T., et al. (1997). Cooperative transformation of NIH3T3 cells by G alpha12 and Rac1. Oncogene 15(6): 727-735.

Toure, A., et al. (1998). MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotund RacGAP gene product, is expressed in male germ cells. J. Biol. Chem. 273(11): 6019-6023.

Tunggal, J. A. et al. (2005). E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24: 1146-1156. 15775979

Turner, C. M. and Adler, P. N. (1998). Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in Drosophila. Mech. Dev. 70(1-2): 181-192

Van Aelst, L., Joneson, T. and Bar-Sagi, D. (1996). Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J 15 (15): 3778-3786.

van Leeuwen, F. N., et al. (1999). Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading. Nat. Cell Biol. 1: 242-248

Vikis, H. G., Li, W. and Guan, K.-L. (2002). The Plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes Dev. 16: 836-845. 11937491

Vincent, S., Settleman, J. (1997). The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization. Mol. Cell. Biol. 17 (4): 2247-2256.

Wada, Y., et al. (1998). Microtubule-stimulated phosphorylation of tau at Ser202 and Thr205 by cdk5 decreases its microtubule nucleation activity. J. Biochem. (Tokyo) 124(4): 738-746

Waterman-Storer, C. M. (1999). Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts. Nat. Cell Biol. 1: 45-50

Weed, S. A., Du, Y. and Parsons, J. T. (1998). Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J. Cell Sci. 111( Pt 16): 2433-2443.

Wegmeyer, H., et al. (2007). EphA4-dependent axon guidance is mediated by the RacGAP α2-Chimaerin. Neuron. 55: 756-767. Medline abstract: 17785182

Wellington, A., et al. (1999). Spire contains actin binding domains and is related to ascidian posterior end mark-5. Development 126: 5267-5274

Werner, L. A. and Manseau, L. J. (1997). A Drosophila gene with predicted rhoGEF, a pleckstrin homology and SH3 domains is highly expressed in morphogenic tissues. Gene 187: 107-114.

West, M. A., et al. (2000). Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation. Curr. Biol. 10: 839-848.

Weston, C., et al. (2000). Agrin-induced Acetylcholine receptor clustering is mediated by the small guanosine triphosphatases Rac and Cdc42. J. Cell Bio. 150: 205-212. 10893268

Wong, L. and Adler, P. (1993). Tissue polarity genes of Drosophila regulate the subcellular loation of prehair initiation in pupal wing cells. J. Cell Biol. 123: 209-221.

Wu, Y.-C., et al. (2002). Distinct Rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth. Dev. Bio. 250: 145-155. 12297102

Xu, Z., Kukekov, N. V. and Greene, L. A. (2003). POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22(2): 252-61. 12514131

Yang, L. and Bashaw, G. J. (2006). Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline. Neuron 52(4): 595-607. Medline abstract: 17114045

Yang, N., et al. (1998). Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393: 809-812.

Zhang, S., et al. (1995). Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270 (41): 23934-23936.

Zhang, Y., Chen, K., Tu, Y. and Wu, C. (2004). Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. J. Biol. Chem. 279(40): 41695-705. 15284246

Zhao, Z. S., et al. (1998). A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol. Cell. Biol. 18(4): 2153-2163.

Zheng, M., Leung, C. L. and Liem, R. K. (1998). Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system. J. Neurobiol. 35(2): 141-59.

Zhou, Z., et al. (2001). The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. Dev. Cell 1: 477-489. 11703939

Return: Rac References part 1/2

date revised:   15 March 2008

 

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