myoblast city

Albert, M. L., Kim, J. I. and Birge, R. B. (2000). alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. Nat. Cell Biol. 2(12): 899-905. 11146654

Brugnera, E. et al. (2002) Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex, Nat. Cell Biol. 4: 574-582. 12134158

Chen, E. H. and Olson, E. N. (2001). Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila. Dev. Cell 1: 705-715. 11709190

Cote, J. F. and Vuori, K. (2002). Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell Sci. 115: 4901-4913. 12432077

Doberstein, S.K., et al. (1997). Genetic analysis of myoblast fusion: blown fuse is required for progression beyond the prefusion complex. J. Cell Biol. 136: 1249-1261

Duchek, P., et al. (2001). Guidance of cell migration by the Drosophila PDGF/VEGF Receptor. Cell 107: 17-26. 11595182

Dohrmann, C., Azpiazu, N. and Frasch, M. (1990). A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis. Genes Dev. 4: 2098-2111

Erickson, M. R., Galletta, B. J. and Abmayr, S. M. (1997). Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. J. Cell Biol. 138(3): 589-603.

Gu, J., et al. (2001). Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway. J. Biol. Chem. 276(29): 27090-7. 11369773

Gumienny, T. L., et al. (2001). Ced-12/elmo, a novel member of the crkii/dock180/rac pathway, is required for phagocytosis and cell migration. Cell 107(1):27-41. 11595183

Harden, N., et al. (1996). A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol. Cell. Biol. 16: 1896-1908.

Hasegawa, H., et al. (1996). DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol. Cell. Biol. 16(4): 1770-6.

Kiyokawa, E., et al. (1998a). Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex. J. Biol. Chem. 273(38): 24479-84.

Kiyokawa, E., et al. (1998b). Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 21: 3331-3336. 9808620

Kobayashi, S., et al. (2001). Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3. Biochem. J. 354(Pt 1): 73-8. 11171081

Klapper, R., et al. (2002). The formation of syncytia within the visceral musculature of the Drosophila midgut is dependent on duf, sns and mbc. Mech Dev. 110(1-2): 85-96. 11744371

Klemke, R.L., et al. (1998). CAS/Crk coupling serves as a 'molecular switch' for induction of cell migration. J. Cell Biol. 140: 961-972

Kunisaki, Y., et al. (2006). DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J. Cell Biol. 174(5): 647-52. Medline abstract: 16943182

Lundquist, E. A., et al. (2001). Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128: 4475-4488. 11714673

Luo, L., et al. (1994). Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8: 1781-1802.

Matsuda, M., et al. (1996). Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. J. Biol. Chem. 271(24): 14468-72.

Moore, C. A., Parkin, C. A., Bidet, Y. and Ingham, P. W. (2007). A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion. Development 134(17): 3145-53. Medline abstract: 17670792

Nolan, K. M., et al. (1998). Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev. 21: 3337-3342. 9808621

Putz, M., et al. (2005). In Drosophila melanogaster, the Rolling pebbles isoform 6 (Rols6) is essential for proper Malpighian tubule morphology. Mech. Dev. 122(11): 1206-17. 16169193

Reddien, P. W. and Horvitz, H. R. (2000). CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat. Cell Biol. 2(3): 131-6. 10707082

Rushton, E., et al. (1995). Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development. Development 121(7): 1979-88.

Tu, Y., Kucik, D. F. and Wu, C. (2001). Identification and kinetic analysis of the interaction between Nck-2 and DOCK180. FEBS Lett. 491(3): 193-9. 11240126

Wu, Y. C. and Horvitz, H. R. (1998). C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 392(6675): 501-4.

Zipkin, I.D., Kindt, R. M. and Kenyon, C. J. (1997). Role of a new Rho family member in cell migration and axon guidance in C. elegans. Cell 90: 883-894

date revised: 15 April 2007

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